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I-Amylase, a-, Aspergillus oryzae CAS:9001-19-8 Intengo Yomkhiqizi
AmI-ylase iyi-enzyme esiza ekuhlukaniseni isitashi sibe ushukela olula njenge-maltose ne-glucose. Ivame ukukhiqizwa izinto eziphilayo ezihlukahlukene, okuhlanganisa amabhaktheriya, isikhunta, nezitshalo.
I-“a-” ku-“a-amylase” ibhekisela kuhlobo lwe-amylase olufaka i-hydrolyze ngqo izibopho zangaphakathi ze-alpha-1,4 glycosidic ngaphakathi kwe-molecule yesitashi. Lokhu kuphumela ekukhiqizweni kwama-polysaccharides amafushane, angahlukaniswa abe yi-glucose ngamanye ama-enzyme e-amylase.
I-Aspergillus oryzae uhlobo lwesikhunta esinezinhlayiya esaziwa ngekhono laso lokukhiqiza inani elikhulu le-amylase. Ivame ukusetshenziswa ezinqubweni zokukhiqiza ama-enzyme ezimbonini ngenxa yomsebenzi wayo onamandla we-amylolytic. Ama-enzyme akhiqizwa yi-Aspergillus oryzae, kufaka phakathi i-a-amylase, asetshenziswa kabanzi ezimbonini ezahlukahlukene, njengokudla, ukwenza ubhiya, izindwangu, kanye nokukhiqiza insipho.
Embonini yokudla, i-a-amylase etholakala ku-Aspergillus oryzae ivame ukusetshenziswa ekubhakeni, ekwenzeni ubhiya, nasekucubunguleni isitashi. Isiza ekuhlukaniseni isitashi enhlama, kumalt, nakwezinye izinto zokusetshenziswa, okwenza kube lula ukuguqulwa kwama-carbohydrate ayinkimbinkimbi abe ushukela olula ongaguqulwa yimvubelo noma amabhaktheriya ngesikhathi sokubilisa. Le enzyme isetshenziswa nasekukhiqizweni kwezindwangu ukuze kube lula ukususwa kwezinto ezisetshenziswa njengesitashi ezindwangu.
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I-Aprotinin CAS: 9087-70-1 Intengo Yomkhiqizi
I-Aprotinin iyisivimbeli semvelo esisekelwe kumaprotheni sama-enzyme ahlukahlukene e-proteolytic, okuhlanganisa i-trypsin, i-chymotrypsin, ne-plasmin. Ivame ukusetshenziswa ezindaweni zezokwelapha, ikakhulukazi ekuhlinzweni kwenhliziyo nemithambo yegazi, ukunciphisa ukopha nokunciphisa ukulahleka kwegazi. I-Aprotinin isebenza ngokuvimbela umsebenzi wala ma-enzyme, ahilelekile ekuqhekekeni kwamahlule egazi kanye nokuwohloka kwe-fibrin, iphrotheni esiza ekwakhekeni kwamahlule. Ngokuvimbela umsebenzi owedlulele we-enzyme, i-aprotinin isiza ukugcina ukuzinza kwamahlule egazi, ngaleyo ndlela inciphise izinkinga zokopha ngesikhathi sokuhlinzwa.
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I-Thrombin CAS:9002-04-4 Intengo Yomkhiqizi
I-Thrombin iyi-enzyme ebalulekile ehilelekile ekujiyeni kwegazi, eyaziwa nangokuthi ukujiya kwegazi. Ikhiqizwa yiprotheni yayo eyandulelayo, i-prothrombin, ngenxa yokulimala noma ukulimala kwemithambo yegazi. I-Thrombin idlala indima ebalulekile ekwakhekeni kwe-blood clot, okusiza ukuvimbela ukopha ngokweqile nokukhuthaza ukuphulukiswa kwenxeba.
Uma isivuliwe, i-thrombin iguqula i-fibrinogen, enye iphrotheni egazini, ibe yi-fibrin. I-Fibrin yakha isakhiwo esifana ne-mesh esibamba ama-platelet namaseli abomvu egazi, sakha i-blood clot ezinzile. I-Thrombin iphinde isebenze nezinye izici zokuqina kwegazi, ikhulise inqubo yokuqina kwegazi.
Ngaphandle kwendima yayo ekwakhekeni kwamahlule, i-thrombin ineminye imisebenzi ebalulekile. Ikhuthaza ukuphulukiswa kwamanxeba ngokukhuthaza ukufuduka nokwanda kwamaseli ahilelekile ekulungisweni kwezicubu. I-Thrombin iphinde isebenze njenge-vasoconstrictor, ibangela ukuthi imithambo yegazi inciphe futhi inciphise ukugeleza kwegazi endaweni yokulimala.
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I-Urease CAS: 9002-13-5 Intengo Yomkhiqizi
I-Urease iyi-enzyme evuselela i-hydrolysis ye-urea ibe yi-ammonia kanye ne-carbon dioxide. Ikhiqizwa yizinto eziphilayo ezihlukahlukene, okuhlanganisa amabhaktheriya, isikhunta, kanye nezitshalo. I-Urease ibalulekile ekugayweni kwe-nitrogen futhi idlala indima ebalulekile ezinqubweni ezahlukene zezinto eziphilayo, njenge-hydrolysis ye-urea ezinso kanye nokumuncwa kwe-nitrogen ezitshalweni. Iphinde ibe nezinhlelo zokusebenza zezimboni, okuhlanganisa ukuhlonza amabhaktheriya akhiqiza i-urease, umanyolo osekelwe ku-urea, kanye nokutholakala kwezithibi ze-urease ekwelapheni izimo ezithile zezokwelapha.
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I-Leupeptin hemisulfate CAS:103476-89-7
I-Leupeptin hemisulfate iyisivimbeli se-protease esivame ukusetshenziswa ocwaningweni lwe-biochemical kanye ne-biomedical. Itholakala kubhaktheriya i-Streptomyces futhi isebenza ngokuvimbela umsebenzi wama-protease ahlukahlukene, okuhlanganisa i-trypsin, i-chymotrypsin, kanye ne-plasmin.
I-Leupeptin hemisulfate ivame ukusetshenziswa ezivivinyweni zelebhu ukuvimbela ukuwohloka kwamaprotheni okungafuneki, njengoba ama-protease engonakalisile amaprotheni nama-peptide, okuthinta imiphumela yokuhlola. Ngokuvimbela umsebenzi we-protease, i-leupeptin hemisulfate isiza ekuqiniseni amaprotheni nokugcina ubuqotho bawo ngesikhathi sokuhlola.
Ngaphezu kwalokho, i-leupeptin hemisulfate isetshenziswe ezifundweni zesiko lamaseli ukuphenya izindima zama-protease ezinqubweni ezahlukahlukene zamaseli, njengokubonisana kwamaseli, i-apoptosis, kanye nokujika kwamaprotheni.
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I-Lipase evela ku-pancreas yengulube i-CAS:9001-62-1
I-Lipase iyi-enzyme ekhuthaza i-hydrolysis yama-lipid, ikakhulukazi ukuwohloka kwama-triglycerides abe ama-fatty acid kanye ne-glycerol. Ikhiqizwa izinto eziphilayo ezahlukahlukene, okuhlanganisa izilwane, izitshalo, kanye nama-microorganisms. I-Lipase idlala indima ebalulekile ekugayweni kokudla, njengoba isiza ekuqhekekeni nasekumuncweni kwamafutha ekudleni emathunjini amancane. Ngaphezu kwalokho, i-lipase inezicelo eziningi ezimbonini ezifana nokucubungula ukudla, ukukhiqiza insipho, imithi, kanye nokukhiqizwa kwe-biofuel. Amandla ayo okusebenzisa i-hydrolyze ama-lipids kuyenza ibe usizo emisebenzini efana nokuguqulwa kwama-lipid, ukuthuthukisa ukunambitheka, kanye nokukhipha uwoyela.
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I-Lysostaphin CAS:9011-93-2 Intengo Yomkhiqizi
I-Lysostaphin iyi-enzyme enamandla yokulwa namagciwane ehlasela futhi ibulale i-Staphylococcus aureus, igciwane elibangela izifo ezahlukahlukene kubantu. Itholakala kubhaktheriya i-Staphylococcus simulans futhi inamandla okudiliza udonga lweseli lwe-S. aureus, okuholela ekubhujisweni kwayo.
I-enzyme ihlose ngqo ungqimba lwe-peptidoglycan lodonga lweseli lebhaktheriya, iphazamise isakhiwo sayo futhi ibangele ukuqedwa kwamagciwane. Le ndlela eyingqayizivele yokusebenza yenza i-lysostaphin isebenze kahle kakhulu ngokumelene nezinhlobo ze-S. aureus, kufaka phakathi lezo ezimelana nama-antibiotic asetshenziswa njalo.
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I-L-Lactate dehydrogenase CAS:9001-60-9
I-L-Lactate dehydrogenase (LDH) iyi-enzyme edlala indima ebalulekile ekusetshenzisweni kwamandla eseli, ikakhulukazi ekuguqulweni kwe-pyruvate ibe yi-lactate. Ikhuthaza ukuguqulwa okuguqukayo kwe-L-lactate ibe yi-pyruvate, isebenzisa i-NAD+ njenge-cofactor.
I-LDH itholakala ezicutshini ezahlukahlukene zomzimba, okuhlanganisa isibindi, inhliziyo, imisipha, kanye namaseli abomvu egazi. Amazinga okusebenza kwayo angasebenza njengophawu lokuxilonga izifo ezithile, njengokulimala kwesibindi, i-myocardial infarction, kanye nezinye izinhlobo zomdlavuza.
Umsebenzi oyinhloko we-LDH ukugcina ibhalansi yamandla eseli ngokwenza kube lula ukuguqulwa kwe-pyruvate, umkhiqizo we-glycolysis, ibe yi-lactate. Le nqubo, eyaziwa ngokuthi i-anaerobic glycolysis, yenzeka lapho kungekho khona umoya-mpilo futhi ivumela amaseli ukuthi aqhubeke nokukhiqiza amandla lapho ukuhlinzekwa komoya-mpilo kulinganiselwe.
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I-Pepsin CAS:9001-76-7 Intengo Yomkhiqizi
I-Pepsin iyi-enzyme yokugaya etholakala esiswini edlala indima ebalulekile ekugayweni nasekuqhekekeni kwamaprotheni. Ingeqembu lama-enzyme abizwa ngokuthi ama-protease, anesibopho sokuqhekeka kwamaprotheni abe ama-peptide amancane nama-amino acid, okuvumela ukuthi amuncwe emathunjini amancane.
I-Pepsin ikhiqizwa futhi ikhiqizwe ngamaseli amboze isisu, aziwa ngokuthi amaseli amakhulu, ngendlela engasebenzi ebizwa ngokuthi i-pepsinogen. Uma ukudla kungena esiswini, kubangela ukukhishwa kwe-asidi esiswini, okuguqula i-pepsinogen ibe yifomu yayo esebenzayo, i-pepsin. I-Pepsin isebenza kahle endaweni ene-asidi, njengoba i-pH ephansi yesisu isiza ukuvuselela nokugcina umsebenzi wayo we-enzyme.
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Isengezo seProtheyini iKinase KT5823 CAS:126643-37-6
Isengezo se-protein kinase i-KT5823 siyisivimbeli esincane sama-molecule esihlasela futhi sivimbele ngqo umsebenzi we-protein kinase. Ama-protein kinase angama-enzyme afaka ama-phosphate amaprotheni ngokufaka amaqembu e-phosphate kuma-amino acid residues athile, ngokuvamile i-serine, i-threonine, noma i-tyrosine. Le nqubo ye-phosphorylation idlala indima ebalulekile ezindleleni ezahlukahlukene zokubonisana kwamaseli, ilawula ukusebenza kweprotheni, futhi ilawula izinqubo zamaseli njengokukhula kwamaseli, ukuhlukana, ukuhlukaniswa, kanye ne-apoptosis.
I-KT5823 ivame ukusetshenziswa ezifundweni zocwaningo ukuphenya umsebenzi kanye nezindlela zokubonisa izimpawu zama-protein kinase. Ngokuvimba ama-protein kinase, i-KT5823 ingasiza abacwaningi ukunquma amaprotheni athile kanye nezindlela ezithintwe umsebenzi we-kinase. Lolu lwazi lungaba nokuqonda ekuqondeni indima yama-protein kinase emisebenzini yamaseli kanye nokuhlonza izinhloso ezintsha zokwelapha.
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I-Pyridoxal-5′-phosphate monohydrate CAS:41468-25-1
I-Pyridoxal-5′-phosphate monohydrate, eyaziwa nangokuthi i-PLP, iyindlela esebenzayo ye-vitamin B6. Iyi-coenzyme ebalulekile ehilelekile ezinhlobonhlobo zezimpendulo ze-enzyme emzimbeni. I-PLP idlala indima ebalulekile ekusetshenzisweni kwe-amino acid, ekwakhiweni kwe-neurotransmitter, kanye nasekwakhiweni kwe-heme, ingxenye ye-hemoglobin.
I-PLP isebenza njenge-coenzyme ngokubopha kuma-enzyme athile nokusiza ekusabeleni kwamakhemikhali. Isebenza njengesikhuthazi, ikhuthaza ukuguqulwa kwezinto ezahlukahlukene, njenge-amino acid, zibe imikhiqizo ehlukene. I-PLP ibaluleke kakhulu ekusetshenzisweni kwama-amino acid, njengokuguqulwa kwe-tryptophan ibe yi-serotonin, noma ukuqhekeka kwe-glycine ibe yi-serine.
Ngaphezu kwendima yayo ekusetshenzisweni kwe-amino acid, i-PLP ibandakanyeka nasekuhlanganisweni kwama-neurotransmitter afana ne-dopamine, i-norepinephrine, kanye ne-gamma-aminobutyric acid (GABA). Lawa ma-neurotransmitter abalulekile ekusebenzeni kahle kobuchopho futhi ahilelekile ekulawulweni kwemizwa, ukuqonda, kanye nokudluliselwa kwezimpawu phakathi kwamaseli ezinzwa.
Ngaphezu kwalokho, i-PLP iyadingeka ekwakhiweni kwe-heme, ingxenye ye-hemoglobin etholakala kumaseli abomvu egazi. I-Hemoglobin inesibopho sokuthwala umoya-mpilo kuwo wonke umzimba, okwenza i-PLP ibaluleke kakhulu ekugcineni amazinga ajwayelekile omoya-mpilo nokuqinisekisa ukusebenza kahle kwezitho nezicubu ezahlukahlukene.
Ngenxa yokubaluleka kwayo ezinqubweni eziningi ze-biochemical, ukwengezwa kwe-PLP ngezinye izikhathi kunconywa kubantu abanezimo ezithile zezokwelapha noma ukuntuleka okuthinta ukusebenza kwe-vitamin B6. Itholakala ngesimo se-supplement futhi inganqunywa abahlinzeki bezempilo ngezidingo ezithile.
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I-Reductase, i-glutathione CAS:9001-48-3
I-Glutathione reductase iyi-enzyme edlala indima ebalulekile ekugcineni ibhalansi ye-glutathione encishisiwe ne-oxidized (GSH/GSSG) emaseli. I-Glutathione iyi-tripeptide eyakhiwe ama-amino acid i-glycine, i-cysteine, ne-glutamate. Isebenza njenge-antioxidant enkulu yamaseli futhi ihilelekile ezinqubweni ezahlukahlukene zamaseli, okuhlanganisa ukukhishwa kwe-detox emzimbeni, ukwakheka nokulungiswa kwe-DNA, kanye nokwakheka kwamaprotheni.
I-Glutathione reductase ikhuthaza ukwehla kwe-glutathione e-oxidized (GSSG) ibe yifomu layo elincishisiwe (GSH) ngokusebenzisa i-NADPH (nicotinamide adenine dinucleotide phosphate) njenge-cofactor. Lokhu kusabela kubalulekile ekugcineni isimo esincishisiwe se-glutathione emaseli, njengoba i-GSSG inganqwabelana lapho kukhona ukucindezeleka kwe-oxidative.
Ngokugcina isilinganiso esifanele se-GSH ku-GSSG, i-glutathione reductase isiza ukuvikela amaseli ekulimaleni kwe-oxidative okubangelwa izinhlobo ze-oxygen (ROS) ezisabelayo kanye namanye ama-molecule ayingozi. Isebenza njengomdlali obalulekile ohlelweni lokuvikela amaseli olune-antioxidant.
Ngaphezu kwalokho, i-glutathione reductase ibandakanyeka ekuvuseleleni i-glutathione disulfide (GSSG) ekhiqizwa ngesikhathi sezinqubo ezahlukahlukene ze-metabolic, okuqinisekisa ukutholakala kwe-glutathione encishisiwe (GSH) yemisebenzi yayo eminingi yamaseli.
