I-L-Lactate dehydrogenase CAS:9001-60-9

Umphumela we-L-Lactate dehydrogenase (LDH) uhlanganisa indima yayo ekusetshenzisweni kwamandla eseli kanye nokubandakanyeka kwayo ekuguqulweni kwe-pyruvate ibe yi-lactate. I-LDH isiza ukugcina ibhalansi yamandla emaseli ngokwenza kube lula ukuguqulwa kwe-pyruvate, umkhiqizo ophuma ku-glucose metabolism, ibe yi-lactate. Le nqubo, eyaziwa ngokuthi i-anaerobic glycolysis, yenzeka lapho ukuhlinzekwa komoya-mpilo kulinganiselwe.

I-LDH idlala indima ebalulekile ekusetshenzisweni kabusha kwe-lactate. Ngesikhathi sokuzivocavoca okukhulu noma lapho ukutholakala komoya-mpilo kuphansi, i-lactate ingaqongelela ezicutshini. I-LDH isiza ukuphinda isebenzise i-lactate ngokuyiguqula ibe yi-pyruvate, engasetshenziswa njengesisekelo sokukhiqizwa kwamandla noma iguqulwe ibe yi-glucose nge-gluconeogenesis. Le ndlela yokuphinda isebenzise i-lactate ivumela amaseli ukuthi asebenzise i-lactate ngempumelelo njengomthombo wamandla futhi isiza ukuvimbela ukunqwabelana kwe-lactate, okungaba yingozi ekusebenzeni kwamaseli.

I-LDH inezinhlelo eziningana emkhakheni wezokwelapha. Enye yezinhlelo zayo ezinkulu iwuphawu lokuxilonga izifo ezithile. Amazinga aphezulu e-LDH egazini angabonisa ukulimala kwezicubu noma ukuba khona kwezifo ezifana nokulimala kwesibindi, i-myocardial infarction, kanye nezinhlobo ezithile zomdlavuza. Amazinga e-LDH avame ukubhekwa ezindaweni zemitholampilo ukuze kuhlolwe ukuqhubeka kwesifo kanye nempendulo ekwelashweni.