Isengezo se-Protein Kinase KT5823 CAS:126643-37-6 Isithombe Esifakiwe

Isengezo seProtheyini iKinase KT5823 CAS:126643-37-6

Isengezo se-protein kinase i-KT5823 siyisivimbeli esincane sama-molecule esihlasela futhi sivimbele ngqo umsebenzi we-protein kinase. Ama-protein kinase angama-enzyme afaka ama-phosphate amaprotheni ngokufaka amaqembu e-phosphate kuma-amino acid residues athile, ngokuvamile i-serine, i-threonine, noma i-tyrosine. Le nqubo ye-phosphorylation idlala indima ebalulekile ezindleleni ezahlukahlukene zokubonisana kwamaseli, ilawula ukusebenza kweprotheni, futhi ilawula izinqubo zamaseli njengokukhula kwamaseli, ukuhlukana, ukuhlukaniswa, kanye ne-apoptosis.

I-KT5823 ivame ukusetshenziswa ezifundweni zocwaningo ukuphenya umsebenzi kanye nezindlela zokubonisa izimpawu zama-protein kinase. Ngokuvimba ama-protein kinase, i-KT5823 ingasiza abacwaningi ukunquma amaprotheni athile kanye nezindlela ezithintwe umsebenzi we-kinase. Lolu lwazi lungaba nokuqonda ekuqondeni indima yama-protein kinase emisebenzini yamaseli kanye nokuhlonza izinhloso ezintsha zokwelapha.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

Isengezo se-protein kinase i-KT5823 siyisivimbeli esivame ukusetshenziswa se-protein kinase G (PKG), esiqondisa ngqo uhlobo lwe-I isoform PKG-1. I-PKG iyi-serine/threonine kinase edlala indima ebalulekile ezinqubweni ezahlukahlukene zamaseli njengokuphumula kwemisipha ebushelelezi, ukuhlanganiswa kwama-platelet, kanye nokulawulwa kokwanda kwemithambo yegazi.

Umphumela oyinhloko we-KT5823 ukuvinjelwa komsebenzi we-PKG-1 ngokuncintisana nokubopha kwe-ATP kusizinda se-kinase. Ngokuvimbela i-PKG-1, i-KT5823 ingaphazamisa izindlela zokubonisa izimpawu ezansi kokusebenza kwe-PKG-1, kufaka phakathi ama-cascade okubonisa izimpawu ancike ku-cGMP.

Ukusetshenziswa kwe-KT5823 kugxile kakhulu ezifundweni zocwaningo ukuze kuhlolwe umsebenzi kanye nezindlela zokubonisa izimpawu ze-PKG-1. Ukusetshenziswa kwayo ekuvimbeleni umsebenzi we-PKG-1 kuvumela abacwaningi ukuthi bahlole izindima ze-PKG-1 ezinqubweni ezahlukahlukene zomzimba kanye nezifo. Ezinye izinhlelo zokusebenza ezithile ze-KT5823 zifaka:

Ukuphenya ngokuphumula kwemisipha ebushelelezi: I-PKG-1 idlala indima ebalulekile ekuphumuleni kwemisipha ebushelelezi. Ngokuvimba i-PKG-1 kusetshenziswa i-KT5823, abacwaningi bangafunda izindlela eziyisisekelo nezindlela ezihilelekile ekuphumuleni kwemisipha ebushelelezi, okubalulekile emikhakheni efana nocwaningo lwenhliziyo nemithambo yegazi.

Ukufunda ukuhlanganiswa kwama-platelet: I-PKG-1 ilawula nokuhlanganiswa kwama-platelet kanye nokwakheka kwama-clot. Ukuvimbela i-PKG-1 nge-KT5823 kuvumela abacwaningi ukuthi bahlole umthelela womsebenzi we-PKG-1 ekusebenzeni kwama-platelet futhi baqonde izindlela ezihilelekile.

Ukuhlola imigomo ye-PKG-1 esezansi: Ngokuvimba i-PKG-1, abacwaningi bangabona futhi bafunde imigomo ye-PKG-1 kanye nezimbangela ze-PKG-1 signaling, banikeze ukuqonda ngezindlela zama-molecule ezisekela izimpendulo zamaseli eziqondiswa yi-PKG-1.

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C29H25N3O5
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	126643-37-6
Ukupakisha	Encane futhi enkulu
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.