I-Leflunomide CAS:75706-12-6 Isithombe Esifakiwe Somhlinzeki Womkhiqizi

I-Leflunomide CAS:75706-12-6 Umhlinzeki Womkhiqizi

I-Leflunomide iyisidakamizwa esilwa nokuvuvukala esitholakala ngomlomo futhi yethulwa njenge-Arava e-US yokwelapha isifo samathambo (RA);ingumuthi wokuqala nowodwa okumele ukhonjiswe ukuthi wehlise ijubane ukulimala kwamalunga esakhiwo se-RA, ngakho-ke ukubhekana nesidingo sezokwelapha esingahlangatshezwana nazo.I-Leflunomide iyisidakamizwa esisebenza ngokushesha futhi esicishe sigaywe ngokuphelele (isigamu sempilo,

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Isicelo kanye Nomphumela

I-Leflunomide ayisebenzi, kodwa i-teriflunomide ivimbela ukuhlanganiswa kwe-pyrimidine de novo ngemithamo ephansi yokwelapha ngokuvimbela i-dihydroorotate dehydrogenase (i-enzyme enquma izinga lokuhlanganiswa kwe-UMP), inciphisa ukuhlanganiswa kwe-DNA ne-RNA, nokubopha umjikelezo wokwanda kwamaseli nokukhiqizwa kwamasosha omzimba.Ukwehliswa kwe-dihydroorotate ukuze i-orotate kwenzeka kanyekanye nokwehliswa kwe-cofactor yayo, i-ubiquinone (coenzyme Q).Ukuvinjelwa kwe-dihydroorotate dehydrogenase nge-teriflunomide kukhombisa i-kinetics engaqhudelani futhi engenakuncintisana.Ukuphathwa kwe-leflunomide ezigulini ezine-rheumatoid arthritis kubangela ukususwa okuqhubekayo kwamaseli B kanye nokulawulwa phansi kwenqubo yokuzivikela komzimba.

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Ulwazi Olwengeziwe:

Ukwakheka	I-C12H9F3N2O2
Isivivinyo	99%
Ukubukeka	Impushana emhlophe
Inombolo ye-CAS.	75706-12-6
Ukupakisha	25KG
I-Shelf Life	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	ISO.