I-Leflunomide CAS:75706-12-6 Umhlinzeki Womkhiqizi

I-Leflunomide umuthi oguqula izifo otholakala ngomlomo futhi wethulwa njenge-Arava e-US ukwelapha i-rheumatoid arthritis (RA); umuthi wokuqala nowodwa kuphela okhonjisiwe ukuthi wehlisa umonakalo wesakhiwo samalunga e-RA, ngakho-ke ubhekana nesidingo sezokwelapha esingakahlangatshezwa. I-Leflunomide umuthi osekela ukugaywa ngokushesha nangokucishe ngokuphelele (ingxenye yempilo, ngaphansi kwemizuzu engama-60) ngemuva kokuphathwa ngomlomo ku-teriflunomide, i-metabolite ye-α-cyanoenol esebenzayo ngokwemithi.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

I-Leflunomide ayisebenzi, kodwa i-teriflunomide ivimbela ukwenziwa kwe-pyrimidine de novo ngemithamo ephansi yokwelapha ngokuvimbela i-dihydroorotate dehydrogenase (i-enzyme enquma izinga lokwenziwa kwe-UMP), ukunciphisa ukwenziwa kwe-DNA ne-RNA, kanye nokuvimba umjikelezo wokwanda kwamaseli kanye nokukhiqizwa kwama-antibodies. Ukwehla kwe-dihydroorotate ku-orotate kwenzeka ngesikhathi esifanayo nokwehla kwe-cofactor yayo, i-ubiquinone (i-coenzyme Q). Ukuvinjelwa kwe-dihydroorotate dehydrogenase yi-teriflunomide kubonisa i-kinetics engancintisani futhi engancintisani. Ukuphathwa kwe-leflunomide ezigulini ezine-rheumatoid arthritis kuphumela ekususweni okuqhubekayo kwamaseli e-B kanye nokwehla kwenqubo yokuzivikela komzimba.

Isampula Yomkhiqizo

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C12H9F3N2O2
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	75706-12-6
Ukupakisha	25KG
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.