I-Letrozole CAS: 112809-51-5 Umkhiqizi Umhlinzeki Isithombe Esivelele

I-Letrozole CAS: 112809-51-5 Umhlinzeki Womkhiqizi

I-Letrozole iyingxenye yesizukulwane esisha sama-aromatase inhibitors akhetha kakhulu futhi iyi-benzotriazole derivative eyenziwe ngokwenziwa. I-Letrozole ivimbela i-aromatase ukwehlisa amazinga e-estrogen, ngaleyo ndlela ivimbele i-estrogen ekukhuthazeni ukukhula kwesimila. Umsebenzi wayo emzimbeni unamandla ngokuphindwe ka-150-250 kunowe-aromatase inhibitor yesizukulwane sokuqala i-Amarante. Njengoba ikhetha kakhulu, ngeke ithinte imisebenzi ye-glucocorticoid, i-mineralocorticoid kanye ne-thyroid; ngisho noma isetshenziswa kakhulu, ngeke ibe nemiphumela evimbelayo ekukhiqizweni kwe-corticosteroid ye-adrenal, okuyinika inkomba ephezulu yokwelashwa.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

I-Letrazole ingakhiwa ngezinyathelo ezimbili kusukela ku-4-bromomethyl-benzonitrile ene-1,2,4-triazole futhi iyisivimbeli sesizukulwane sesithathu se-aromatase. Iyisivimbeli esiqondile kakhulu se-P450arom esivimbela ukuguqulwa kwe-androstenedione ibe yi-estrone. Ukwehla kwe-estrogen ye-plasma kwashesha futhi kwahlala isikhathi eside. Lokhu kufezwa ngaphandle kokuvinjelwa kwezinye izinto zokwenziwa kwe-steroid okwenza kube yi-aromatase inhibitor ekhethiwe kakhulu ehlolwe. I-Letrazole inomsebenzi omangalisayo wokulwa nomdlavuza, ibekezelelwa kahle futhi ayinayo imiphumela emibi enobuthi. Inamandla ngokuphindwe kayi-10,000 kune-aminoglutethimide, in vivo, i-aromatase inhibitor yokuqala esungulwe kahle.

Isampula Yomkhiqizo

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C17H11N5
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	112809-51-5
Ukupakisha	25KG
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.