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I-N,N-Bis(2-hydroxyethyl) -2-aminoethanesulfonic acid sodium usawoti CAS:66992-27-6
I-N,N-Bis(2-hydroxyethyl) -2-aminoethanesulfonic acid usawoti we-sodium, owaziwa nangokuthi usawoti we-sodium we-HEPES, uyinhlanganisela yamakhemikhali evamise ukusetshenziswa njenge-ejenti egcina i-pH kumalabhorethri ebhayoloji namakhemikhali.Isiza ukugcina ububanzi be-pH obuzinzile, buyenze ilungele izinhlelo zokusebenza ezifana nesiko lamaseli, ukuhlolwa kwe-enzyme, izifundo zamaprotheni, i-electrophoresis, nokwakheka kwemithi.Usawoti we-sodium we-HEPES uqinisekisa izimo ezifanele zezinqubo zebhayoloji futhi uthuthukisa ukunemba nokuthembeka kwemiphumela yokuhlola.
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2′-(4-METHYLUMBELLIFERYL)-ALPHA-DN-ACETYLNEURAMINIC ACID SODIUM SALT CAS:76204-02-9
I-2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid usawoti we-sodium iyinhlanganisela yamakhemikhali evame ukusetshenziswa ekuhloleni nasekuhloleni ucwaningo.Iwukuphuma okune-fluorescent okubhalwe ukuthi i-sialic acid, uhlobo lwe-carbohydrate etholakala ebusweni bamaseli.
Le nhlanganisela isetshenziswa njenge-substrate yama-enzyme abizwa ngokuthi ama-neuraminidases, asebenza ukususa izinsalela ze-asilic acid kuma-glycoprotein nama-glycolipids.Uma lawa ma-enzyme enza ku-2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid usawoti we-sodium, ukhulula umkhiqizo we-fluorescent owaziwa ngokuthi i-4-methylumbelliferon.
I-fluorescence ekhiqizwa yi-compound ingalinganiswa futhi inqunywe, inikeze ulwazi ngomsebenzi we-neuraminidase enzymes.Lokhu kuwusizo ikakhulukazi ekutadisheni izifo ezihlukahlukene nezimo ezihlobene ne-aberrant sialic acid metabolism.
Inhlanganisela iphinde isetshenziselwe izinjongo zokuxilonga, njengokutholwa kwezifo ezibangelwa amagciwane ezibandakanya umsebenzi we-neuraminidase.Kulezi zivivinyo, inhlanganisela isetshenziselwa ukukhomba ukuba khona kwezinhlobo ezithile zegciwane noma ukuhlola ukusebenza kwe-neuraminidase inhibitors ekwelashweni kwe-antiviral.
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I-TAPSO CAS:68399-81-5 Intengo Yomkhiqizi
I-TAPSO (3--[N-tris(hydroxymethyl)methyl]amino]-2-hydroxypropanesulfonic acid) iyibhafa ye-zwitterionic evamise ukusetshenziswa ocwaningweni lwebhayoloji nolwe-biochemical.Kuyi-ejenti esebenzayo yokubhafa ene-pKa eseduze ne-pH yezemvelo, okuyenza ifaneleke ukugcina i-pH ezinzile ekuhlolweni kwebhayoloji.I-TAPSO ivame ukusetshenziswa ekuhlanzeni amaprotheni, ekuhlolweni kwe-enzyme, isiko lamaseli, kanye nezicelo ze-electrophoresis.Ukuncibilika kwayo okuphezulu kwamanzi kanye nokuphazamiseka okuphansi kwezinqubo zebhayoloji kuyenza ibe ukukhetha okudumile emphakathini wesayensi.I-TAPSO yaziwa ngomthelela wayo omncane emsebenzini we-enzyme futhi ivamise ukusetshenziswa njengenye indlela kwamanye ama-ejenti agcina imali njenge-Tris noma amabhafa e-phosphate.
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I-N-Acetyl-L-cysteine CAS: 616-91-1
I-N-Acetyl-L-cysteine (NAC) iwuhlobo oluguquliwe lwe-amino acid cysteine.Ihlinzeka ngomthombo we-cysteine futhi ingaguqulwa kalula ibe i-tripeptide glutathione, i-antioxidant enamandla emzimbeni.I-NAC yaziwa ngezakhiwo zayo ze-antioxidant kanye ne-mucolytic, okuyenza ibe wusizo ezinhlelweni ezahlukahlukene zezempilo.
Njenge-antioxidant, i-NAC isiza ukuvikela amaseli emonakalweni obangelwa ama-radicals mahhala, izinhlobo ze-oxygen esebenzayo, kanye nobuthi.Iphinde isekele i-glutathione synthesis, edlala indima ebalulekile ezinqubweni zokukhipha ubuthi emzimbeni kanye nokugcina amasosha omzimba anempilo.
I-NAC icwaningwe ngezinzuzo zayo ezingaba khona empilweni yokuphefumula, ikakhulukazi kubantu abanezimo ezifana ne-bronchitis engapheli, i-COPD, ne-cystic fibrosis.Ivamise ukusetshenziswa njenge-expectorant ukusiza amafinyila azacile futhi axege, okwenza kube lula ukusula imigudu yomoya.
Ngaphezu kwalokho, i-NAC ibonise isithembiso ekusekeleni impilo yesibindi ngokusiza ekukhipheni izinto ezinobuthi, njenge-acetaminophen, isidambisi sobuhlungu esivamile.Kungase futhi kube nemiphumela yokuzivikela ekulimaleni kwesibindi okubangelwa ukuphuza utshwala.
Ngaphezu kwezakhiwo zayo zokusekela i-antioxidant nokuphefumula, i-NAC iye yahlolwa ngezinzuzo zayo ezingaba khona empilweni yengqondo.Olunye ucwaningo lubonisa ukuthi kungase kube nomthelela omuhle ezinkingeni zemizwa, njengokucindezeleka kanye nesifo esicindezelayo (OCD).
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PIPES CAS:5625-37-6 Intengo Yomkhiqizi
PIPES (piperazine-1,4-bisethanesulfonic acid) iyinhlanganisela ye-zwitterionic buffering evame ukusetshenziswa ocwaningweni lwebhayoloji nolwe-biochemical.Iyisivikelo se-pH esisebenzayo esinamandla aphezulu wokugcina izimo ze-pH ezinzile ebangeni le-pH lika-6.1 kuya ku-7.5.I-PIPES inokuphazanyiswa okuncane kwama-biomolecules futhi ifanele ukuhlolwa okuncike kukushisa.Ivame ukusetshenziswa kumasu we-gel electrophoresis kanye nokwakhiwa kwemithi njenge-ejenti yokuzinzisa.Sekukonke, PIPES iyinhlanganisela eguquguqukayo futhi esetshenziswa kabanzi kuzilungiselelo ezahlukahlukene zokuhlola.
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2′,6′-DiMethylcarbonylphenyl-10-sulfopropylacridiniumM-9-carboxylate 4′-NHS Ester CAS:194357-64-7
I-2',6'-DiMethylcarbonylphenyl-10-sulfopropylacridinium-9-carboxylate 4'-NHS ester iyinhlanganisela yamakhemikhali enesakhiwo esiyinkimbinkimbi samangqamuzana.Iqukethe iqembu le-sulfopropylacridinium kanye neqembu elisebenzayo le-carboxylate ester.Ukuba khona kwe-ester moiety kubonisa ukuthi iyasebenza futhi ingasetshenziswa njengelebula noma i-ejenti eshintshayo yama-biomolecules.
Iqembu lenhlanganisela ye-sulfopropylacridinium liphakamisa ukuthi lingase libe nokusetshenziswa okungase kube khona ekuhlolweni okusekelwe ku-fluorescence, lapho lingasetshenziswa khona njenge-fluorescent probe noma udayi ukuze kutholwe futhi kuhlaziywe ama-biomolecules.Kungase futhi kube nokubaluleka ezifundweni zezinqubo zamaselula, njengokusayina kwe-calcium ye-intracellular.
Ukufakwa kweqembu le-ester le-NHS kubonisa ukuthi lingasabela ngama-amine ayinhloko, njengalawo atholakala kumaprotheni noma ama-peptide, ukuze enze izibopho eziqinile ze-amide.Lokhu kuphinda kusebenze kuyenza ibe wusizo ezinhlelweni zokusebenza ze-bioconjugation, lapho ingasetshenziswa ukulebula noma ukuguqula ama-biomolecules namanye ama-molecule asebenzayo, njenge-fluorophores noma omaka.
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5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide CAS:4264-82-8
I-5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide iyinhlanganisela esetshenziswa ezifundweni ezihlukahlukene ze-biochemical, ikakhulukazi ukuze kutholwe futhi kubonakale umsebenzi we-enzyme.Kuyi-substrate engenziwa i-hydrolyzed ngama-enzyme athile, okuholela ekukhululweni komkhiqizo onemibala noma we-fluorescent.
Le nhlanganisela ivame ukusetshenziswa ekuhloleni ukuthola ubukhona nomsebenzi wama-enzyme afana ne-beta-galactosidase ne-beta-glucuronidase.Lawa ma-enzyme ahlukanisa amaqembu e-acetyl ne-glucosaminide ku-substrate, okuholela ekwakhekeni kwechromophore eluhlaza okwesibhakabhaka noma eluhlaza.
Isakhiwo esiyingqayizivele se-5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide sivumela ukutholakala kalula kanye nokulinganisa umsebenzi we-enzyme.Ukusetshenziswa kwayo kumasu okuhlola ahlukahlukene, okuhlanganisa i-histochemistry, i-immunohistochemistry, nokuhlola okusekelwe kumaseli, kube negalelo ekuqondeni kangcono imisebenzi yama-enzyme.
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I-Sodium Salt Salt CAS: 139-41-3 Intengo Yomkhiqizi
I-N,N-Bis(2-hydroxyethyl) usawoti we-glycine sodium iyinhlanganisela yamakhemikhali esetshenziswa njenge-ejenti ephazamisayo emisebenzini ehlukahlukene ye-biochemical and biophysical.Isiza ukugcina izinga le-pH elizinzile ezimeni zokuhlola, iyenze ibe usizo ezifundweni zama-enzyme, ucwaningo lwamaprotheni, isiko lamaseli, nezindlela zokuvala zaseNtshonalanga.
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Spinosad CAS:131929-60-7 Umkhiqizi Supplier
I-Spinosad iyiqembu le-5 i-nicotinic acetylcholine receptor agonist, elibangela ukufinyela kwemisipha okungahleliwe kanye nokundindizela okwesibili kuya ku-motor neuron activation.Ukuchayeka isikhathi eside kubangela ukukhubazeka nokufa kwamazeze.Ukufa kwezinambuzane kuqala kungakapheli imizuzu engama-30 ngemuva kokuthatha umthamo futhi emahoreni ama-4 sekuqediwe.I-Spinosad ayihlangani nezindawo zokubopha zamanye ama-insecticidal agents (GABA-ergic noma i-nicotinic).
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Rotenone CAS:83-79-4 Umkhiqizi Supplier
I-Rotenone kokubili yisisu kanye nobuthi obuthinta ama-arthropods.Isenzo sayo sokuwisa ngokushesha sibangelwa ukuncipha kokutholakala kwe-nicotinamide adenine dinucleotide ukuze isebenze njenge-cofactor ezindleleni ezihlukahlukene ze-biochemical kuhlanganise nomjikelezo we-Krebs, ngaleyo ndlela ivimbele ama-enzyme okuphefumula e-mitochondrial.
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Diazinon CAS:333-41-5 Umkhiqizi Supplier
I-Diazinon itholakala ngendlela yoketshezi olungenambala noma olunsundu ngokumnyama.Incibilika kancane emanzini kodwa incibilika ku-petroleum ether, utshwala, ne-benzene.I-Diazinon isetshenziselwa ukulawula izinhlobonhlobo zezolimo nezinambuzane zasendlini.Lokhu kuhlanganisa izinambuzane enhlabathini, ezitshalweni zokuhlobisa, izithelo, imifino, izitshalo kanye nezinambuzane zasendlini njengezimpukane, amazeze namaphela.
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I-Avermectin CAS:71751-41-2 Umkhiqizi Umphakeli
I-Abamectin (i-Avermectin) iyi-ejenti enobuthi ezinzwa.Indlela yayo iqondise ku-GABAA receptor ye-insect neuron synapse noma i-neuromuscular synapse, ephazamisa ukudluliswa kolwazi lweziphetho zemizwa, okuwukuthi ukuvuselela iziphetho zemizwa ukuze kukhishwe i-neurotransmitter inhibitor γ-aminobutyric acid (GA-BA), okudala ukuvulwa okubanzi kwe-nerve. Isiteshi se-GABA-gated chloride esinomphumela wokuvuselela isiteshi se-chloride.
