2′-(4-METHYLUMBELLIFERIFERYL)-ALPHA-DN-ACETYLNEURAMINIC ACID SODIUM USAWOTI CAS:76204-02-9

I-2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid usawoti we-sodium uyinhlanganisela yamakhemikhali evame ukusetshenziswa ekuhlolweni kokuxilonga nokucwaninga. Kuyi-derivative ebhalwe nge-fluorescent ye-sialic acid, uhlobo lwe-molecule yama-carbohydrate etholakala ebusweni bamaseli.

Le nhlanganisela isetshenziswa njengesisekelo sama-enzyme abizwa ngokuthi ama-neuraminidases, asebenza ukususa izinsalela ze-sialic acid kuma-glycoprotein nama-glycolipid. Lapho la ma-enzyme esebenza kusawoti we-sodium we-2′-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid, ikhipha umkhiqizo okhanyayo owaziwa ngokuthi yi-4-methylumbelliferone.

Ukugqama okukhiqizwa yile nhlanganisela kungalinganiswa futhi kulinganiswe, kuhlinzekwe ulwazi ngomsebenzi wama-enzyme e-neuraminidase. Lokhu kuwusizo kakhulu ekufundweni kwezifo nezimo ezahlukahlukene ezihlobene nokuguqulwa kwe-aberrant sialic acid.

Le nhlanganisela isetshenziselwa nezinjongo zokuxilonga, njengokuthola izifo ezibangelwa amagciwane ezibandakanya umsebenzi we-neuraminidase. Kulezi zivivinyo, le nhlanganisela isetshenziselwa ukuhlonza ukuba khona kwezinhlobo ezithile zamagciwane noma ukuhlola ukusebenza kahle kwezithiyo ze-neuraminidase ekwelashweni kwe-antiviral.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

Ukuhlolwa Komsebenzi we-Neuraminidase: Le nhlanganisela ivame ukusetshenziselwa ukukala umsebenzi wama-enzyme e-neuraminidase kumasampula ebhayoloji. Ngokuqapha ukukhanya okukhiqizwayo, abacwaningi banganquma izinga lomsebenzi we-neuraminidase, okungasiza ekufundweni kwezifo nezimo ezahlukahlukene.

Ukutholwa Kokutheleleka Ngegciwane: Izifo eziningi zegciwane, okuhlanganisa nomkhuhlane, zihilela umsebenzi we-neuraminidase. Le nhlanganisela ingasetshenziswa ukuthola nokulinganisa ukuba khona kwezinhlobo ezithile zegciwane ngokulinganisa umsebenzi we-fluorescent. Iwusizo kakhulu ekuhloleni ukusebenza kahle kwezithibi ze-neuraminidase ekwelashweni kwe-antiviral.

Ukuhlaziywa kwe-Glycosylation: I-Sialic acid iyisici esibalulekile sama-glycoprotein nama-glycolipid. Ngokufaka usawoti we-sodium ongu-2'-(4-Methylumbelliferyl)-alpha-DN-acetylneuraminic acid ezivivinyweni, abacwaningi bangathola ukuqonda nge-metabolism ye-sialic acid, amaphethini e-glycosylation, kanye nezinqubo ezihlobene ne-physiological.

Ukutholakala Kwemithi: Ama-Neuraminidase inhibitors ayiqembu lemithi esetshenziswa ekwelapheni izifo ezibangelwa amagciwane. Leli khemikhali lingasetshenziswa ezifundweni zokutholakala kwemithi, lisiza abacwaningi ukuhlonza nokuhlola ama-inhibitor angaba khona omsebenzi we-neuraminidase.

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C21H26NNaO11
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	76204-02-9
Ukupakisha	Encane futhi enkulu
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.