I-Fmoc-Asp(OBzl)-OH CAS:86060-84-6

I-Fmoc-Asp(OBzl)-OH idlala indima ebalulekile ekwakhiweni kwama-peptide, ikakhulukazi ekwakheni ama-peptide aqukethe i-aspartic acid ngokunemba. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwama-peptide, kuyilapho iqembu le-benzyl lengeza ungqimba olwengeziwe lokuvikela eqenjini le-carboxyl. Abacwaningi basebenzisa kakhulu i-Fmoc-Asp(OBzl)-OH ekwakhiweni kwama-peptide ezinhlelo zokusebenza ezahlukahlukene, okuhlanganisa ukuthuthukiswa kwemithi, izinto eziphilayo, kanye nokuklama ama-peptide asebenzayo anezici ezithile zesakhiwo. Ukuhambisana kwayo nezindlela ezijwayelekile zokwenziwa kwama-peptide, kokubili kumasu esigaba esiqinile kanye nesigaba sesisombululo, kuthuthukisa ukuguquguquka kwayo emizamweni yocwaningo eyahlukahlukene. Ukususwa okulawulwayo kwamaqembu avikelayo kuvumela ukufakwa kwe-aspartic acid ngamasu okulandelana kwama-peptide, kwandise ububanzi bama-peptide angenziwa. Ngaphezu kwalokho, i-Fmoc-Asp(OBzl)-OH ithola usizo ekwakhiweni kwama-peptide ocwaningo lwe-proteomics kanye nokufunda izinqubo zamaseli. Ukusetshenziswa okunesu kweqembu lokuvikela i-benzyl kwenza kube lula ukuphathwa ngendlela enembile kwe-aspartic acid reactivity, okunikeza abacwaningi ithuluzi eliwusizo lokuklama ama-peptide anezinguquko ezenziwe ngokwezifiso. Ngamafuphi, i-Fmoc-Asp(OBzl)-OH imele njengethuluzi eliguquguqukayo nelibalulekile kumakhemikhali e-peptide, okunika abacwaningi amandla okuhlola nokuguqula i-aspartic acid reactivity yezinhlelo zokusebenza eziningi zesayensi, ikakhulukazi ukugxila kuma-peptide aqukethe le amino acid ebalulekile.