I-Trt-Gly-OH CAS:5893-05-0

I-Bz-His-OMe idlala indima ebalulekile ekwakhiweni kwe-peptide, isebenza njengesisekelo esibalulekile sokwakha ama-peptide anezici ezithile zesakhiwo nokusebenza. Iqembu elivikela i-benzyl liqinisekisa ukuthi i-histidine residue ihlala ingashintshiwe ngesikhathi sezinqubo zokwenziwa kwe-peptide, okuvumela ukuhlanganiswa kwe-peptide okunembile nokulawulwayo. Ngaphezu kwalokho, ukuba khona kweqembu le-methyl ester kuthonya ukusabela kwamakhemikhali kanye nokusebenzisana kwe-hydrophobic kwe-peptide, okwenza kube usizo ekwakhiweni kwama-peptide anokuvuleka kwe-membrane okuthuthukisiwe noma amakhono athile okukhomba. Ekuthuthukisweni kwemithi, le nhlanganisela ingasetshenziswa ukudala izidakamizwa ezisekelwe ku-peptide ngokuqina okuthuthukisiwe kanye nokutholakala kwe-bioavailability, okungenzeka kuholele ekusebenzeni kahle kokwelapha okuthuthukisiwe. Ngaphezu kwendima yayo ekwakhiweni kwe-peptide, i-Bz-His-OMe ithola ukusetshenziswa ocwaningweni lwe-proteomics kanye ne-biochemical, lapho ingasetshenziswa khona ukutadisha ukusebenzisana kwamaprotheni nama-protein, ukuphenya imisebenzi ye-enzyme, nokuhlola izinguquko zesakhiwo ezincike ku-pH kuma-protein. Isakhiwo sayo esilungiselelwe sivumela abacwaningi ukuthi bahlole ubunzima bezinqubo zamaseli kanye nezindlela zezifo, okunegalelo ekuthuthukisweni kokuqonda impilo kanye ne-pathology. Ukuguquguquka kanye nokuhambisana kwale nhlanganisela nezimo ezahlukahlukene zokuhlola kwenza kube yingxenye ebalulekile yokwembula ubunzima bezinhlelo zezinto eziphilayo kanye nokuthuthukisa ukungenelela okuqondiswe ezimweni ezahlukene zezokwelapha. Ngamafuphi, i-Bz-His-OMe imele ithuluzi eliwusizo kubacwaningi ekuhlanganisweni kwama-peptide, ekuthuthukisweni kwemithi, kanye nasezifundweni ze-biochemical, enikeza ikhono lokulungisa ama-peptide anezakhiwo ezithile futhi ahlukanise izindlela eziyisisekelo zezinqubo zezinto eziphilayo, ngaleyo ndlela inikele ekuthuthukisweni kwezokwelapha kanye ne-biotechnology.