I-Fmoc-D-Asp(OBut)-OH CAS:112883-39-3

I-Fmoc-D-Asp(OBut)-OH isebenza njengengxenye eyisisekelo ekwakhiweni kwama-peptide, ikakhulukazi ekwakheni ama-peptide aqukethe i-D-enantiomer ye-aspartic acid ngokunemba. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwama-peptide, kuyilapho iqembu le-O-butyl lengeza ungqimba olwengeziwe lokuvikela eqenjini le-carboxyl. Abacwaningi basebenzisa kakhulu i-Fmoc-D-Asp(OBut)-OH ekwakhiweni kwama-peptide ezinhlelo zokusebenza ezahlukahlukene, okuhlanganisa ukuthuthukiswa kwemithi, izinto eziphilayo, kanye nokuklama ama-peptide asebenzayo anezici ezithile zesakhiwo. Ukuhambisana kwayo nezindlela ezijwayelekile zokwenziwa kwama-peptide, kokubili kumasu esigaba esiqinile kanye nesigaba sesisombululo, kuthuthukisa ukuguquguquka kwayo emizamweni yocwaningo eyahlukahlukene. Ukususwa okulawulwayo kwamaqembu avikelayo kuvumela ukufakwa okunesu kwe-D-aspartic acid kuchungechunge lwama-peptide, kwandise ububanzi bama-peptide angenziwa. Ngaphezu kwalokho, i-Fmoc-D-Asp(OBut)-OH ithola usizo ekwakhiweni kwama-peptide ocwaningo lwama-proteomics kanye nokufunda izinqubo zamaseli. Ukusetshenziswa okunesu kweqembu lokuvikela i-O-butyl kwenza kube lula ukuphathwa ngendlela enembile kwe-D-aspartic acid reactivity, okunikeza abacwaningi ithuluzi eliwusizo lokuklama ama-peptide anezinguquko ezenziwe ngokwezifiso. Ngamafuphi, i-Fmoc-D-Asp(OBut)-OH imele njengethuluzi eliguquguqukayo nelibalulekile kumakhemikhali e-peptide, okunika abacwaningi amandla okuhlola nokuguqula i-D-aspartic acid reactivity yezinhlelo zokusebenza eziningi zesayensi, ikakhulukazi ukugxila kuma-peptide aqukethe le amino acid ebalulekile.