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I-Adenosine CAS:58-61-7
I-Adenosine iyi-nucleoside eyakhiwe yi-adenine ne-ribose, edlala indima ebalulekile ekusetshenzisweni kwamaseli. Isebenza njengesisekelo sokwakha i-adenosine triphosphate (ATP), uhlobo lwamandla oluyinhloko ezinhlelweni zezinto eziphilayo. Ngaphandle kwemisebenzi yayo ehlobene namandla, i-adenosine ihilelekile ezinqubweni ezahlukene zomzimba, okuhlanganisa ukudluliselwa kwemizwa, ukujikeleza kwegazi, kanye nokulawula umjikelezo wokulala nokuvuka. Isebenza kuma-receptor athile, ithonya izinga lokushaya kwenhliziyo kanye nokugeleza kwegazi. Ngokwezokwelapha, i-adenosine isetshenziswa kwezokwelapha, ikakhulukazi ekwelapheni ama-arrhythmia athile enhliziyo. Izindima zayo eziningi zigcizelela ukubaluleka kwe-adenosine kokubili empilweni nasezifweni.
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I-Uridine 5-monophosphate, usawoti we-disodium I-CAS:3387-36-8
I-Uridine 5-monophosphate, usawoti we-disodium (UMP) iyi-nucleotide edlala indima ebalulekile ekusetshenzisweni kwamaseli kanye nokwakheka kwe-RNA. Ihlanganisa i-pyrimidine base uracil, ushukela we-ribose, kanye neqembu le-phosphate, i-UMP ibalulekile ezinqubweni ezahlukahlukene zezinto eziphilayo, okuhlanganisa ukwakheka kwama-nucleic acid kanye nokulawulwa kwezindlela ze-metabolic. Uhlobo lwe-disodium salt luthuthukisa ukuncibilika kwayo kanye nokuqina kwezixazululo zamanzi, okwenza ifaneleke kokubili ocwaningweni lwelabhorethri kanye nezicelo zokwelapha. I-UMP ithole ukunakwa ngezakhiwo zayo ezingaba khona zokuvikela izinzwa kanye nokuthuthukisa ingqondo, kanye nendima yayo ekukhuthazeni impilo yonke yamaseli.
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I-Cytidine 5′- (i-disodium phosphate) I-CAS:6757-06-8
I-Cytidine 5′- (disodium phosphate) iyi-nucleotide derivative eyakhiwe yi-pyrimidine base cytosine, ushukela we-ribose, kanye neqembu le-phosphate. Le khompawundi idlala indima ebalulekile ezinqubweni ezahlukahlukene ze-biochemical, okuhlanganisa ukwakheka kwe-RNA, izindlela zokulawula, kanye nokubonisana kwamaseli. Uhlobo lwe-disodium salt luthuthukisa ukuncibilika kwayo kanye nokuqina ezimweni zomzimba, okwenza ifanelekele ucwaningo lwelabhorethri kanye nezicelo zokwelapha ezingaba khona. I-Cytidine 5′- (disodium phosphate) ithole isithakazelo ngokubandakanyeka kwayo ku-metabolism ye-nucleic acid kanye nezinzuzo zayo ezingaba khona ekuthuthukiseni umsebenzi wokuqonda kanye nokusekela impilo yamaseli.
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I-5-Azacytidine CAS:320-67-2
I-5-Azacytidine iyi-analogue ye-cytidine eyenziwe nge-nucleoside equkethe i-athomu ye-nitrogen endaweni engu-5 yendandatho ye-pyrimidine, ethatha indawo ye-athomu yekhabhoni. Lokhu kuguqulwa kunikeza izakhiwo zemithi ezihlukile, okwenza kube yikhompiyutha ebalulekile ku-biology yamangqamuzana kanye nokwelashwa komdlavuza. Njengesivimbeli esinamandla se-DNA methyltransferase, i-5-azacytidine ingavuselela izakhi zofuzo ezithulile ngokushintsha amaphethini e-methylation ye-DNA, ngaleyo ndlela ithonye ukubonakaliswa kwezakhi zofuzo. Ekuqaleni yaklanywa ukwelapha umdlavuza we-hematologic, i-5-azacytidine ithole ukunakwa ngezicelo zayo ezingaba khona ekwelashweni kwe-epigenetic, ekwelashweni okuvuselelayo, kanye nocwaningo oluqondiswe ezifweni ezahlukahlukene ezibonakala ngokulawulwa kwezakhi zofuzo okungavamile.
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I-2′-Fluoro-2′-deoxyuridine CAS:784-71-4
I-2′-Fluoro-2′-deoxyuridine (FdU) iyi-analog ye-nucleoside ye-deoxyuridine, lapho i-athomu ye-hydrogen endaweni ye-2′ yoshukela we-ribose ithathelwa indawo yi-athomu ye-fluorine. Lokhu kuguqulwa kuthuthukisa ukuzinza nokusebenza kwe-bioactivity ye-compound, okwenza ibe wusizo ocwaningweni lwe-biochemical kanye nezicelo zokwelapha. I-FdU yaziwa kakhulu ngendima yayo njenge-antiviral kanye ne-anticancer agent, njengoba ingaphazamisa ukwakheka kwe-DNA futhi ivimbele ukuphindaphindeka kwamagciwane athile kanye namaseli omdlavuza. Izakhiwo zayo ezihlukile ziyenza ibe ithuluzi elibalulekile ekuthuthukisweni kwezindlela zokwelapha eziqondiwe kanye nezifundo ze-molecular biology.
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![I-4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
I-4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
I-4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one iyi-analog ye-nucleoside eyinkimbinkimbi enesisekelo se-pyrimidine esinamathiselwe kushukela we-ribose oguquliwe. Ukuba khona kwe-athomu ye-fluorine namaqembu e-hydroxyl esakhiweni sayo kuthuthukisa izakhiwo zayo ze-biochemical, okwenza kube yinto ethakazelisayo yocwaningo lwe-antiviral kanye ne-anticancer. Le nhlanganisela inezinhlelo zokusebenza ezingaba khona kumakhemikhali ezokwelapha, ikakhulukazi njenge-ejenti yokwelapha eqondisa ukwakheka kwe-nucleic acid kanye nezindlela ze-metabolic ezilwaneni ezibangela izifo. Izici zayo ezihlukile zesakhiwo zivumela ukusebenzisana okungcono nezinhloso zezinto eziphilayo ezihilelekile ku-metabolism ye-DNA ne-RNA.
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I-1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
I-1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose iwuhlobo lwe-ribose oluguqulwe ngamakhemikhali, oluqukethe amaqembu amathathu e-benzoyloxy anamathele ezikhundleni ze-1, 3, kanye ne-5 zesakhiwo se-ribofuranose. Lokhu kuguqulwa kuthuthukisa ukuncibilika kwayo kanye nokuqina, okwenza ibe usizo ekusetshenzisweni okuhlukahlukene kokwenziwa kumakhemikhali e-organic kanye ne-biochemistry. Njenge-derivative evikelwe ye-ribose, isebenza njengomxhumanisi ekwakhiweni kwama-nucleoside nama-nucleotide, izingxenye ezibalulekile ze-RNA ne-DNA. Izakhiwo zayo eziyingqayizivele zenza i-1,3,5-tri-O-benzoyl-alpha-D-ribofuranose ibe usizo kubacwaningi abafuna ukuthuthukisa ama-ejenti amasha okwelapha kanye nezinto zokwakha kumakhemikhali e-nucleotide.
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I-2′-O-methyluridine CAS:2140-76-3
I-2′-O-Methyluridine iyi-nucleoside eyenzeka ngokwemvelo lapho iqembu le-methyl linamathele khona ku-athomu ye-oxygen yesikhundla se-2′ soshukela we-ribose ku-uridine. Lokhu kuguqulwa kuthuthukisa ukuzinza nokusebenza kwama-molecule e-RNA, okwenza kube yingxenye ebalulekile ezinqubweni ezahlukahlukene zebhayoloji. I-2′-O-Methyluridine idlala indima ebalulekile esakhiweni nasemsebenzini wama-ribonucleic acid (ama-RNA), okuhlanganisa i-messenger RNA (mRNA) kanye ne-transfer RNA (tRNA). Ukuba khona kwayo kungathinta ukuzinza kwe-RNA, ukusebenza kahle kokuhumusha, kanye nokusebenzisana namaprotheni namanye ama-nucleic acid, okwenza kube yinto ebalulekile ekufundweni kwe-molecular biology kanye nezicelo zokwelapha.
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i-adenosine 5′-monophosphate sodium*kusuka kumvubelo i-CAS:4578-31-8
I-Adenosine 5′-monophosphate sodium (AMP) iyi-nucleotide etholakala ku-adenosine edlala indima ebalulekile ekusetshenzisweni kwe-metabolism yamaseli. I-AMP ibalulekile ezinqubweni ezahlukahlukene zebhayoloji, okuhlanganisa ukudluliselwa kwamandla, ukudluliselwa kwesignali, kanye nokwandulela ukwenziwa kwe-ATP namanye ama-nucleotide. Uhlobo lwe-sodium salt lwe-AMP lungatholakala kwimvubelo, ecebile ngama-nucleotide ngenxa yezindlela zayo ezisebenzayo ze-metabolism. Le nhlanganisela ivame ukusetshenziswa ku-biochemistry kanye ne-pharmacology njenge-reagent yamakhemikhali, isithasiselo sokudla, kanye nesengezo sokudla, ngenxa yezinzuzo zayo zezempilo ezingaba khona kanye nezicelo ekukhuthazeni i-metabolism yamandla.
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I-2′-Deoxycytidine CAS:951-77-9
I-2′-Deoxycytidine iyi-nucleoside eyakhiwe ushukela we-deoxyribose kanye ne-cytosine, ehlukaniswa ukungabikho kweqembu le-hydroxyl endaweni ye-2′ ye-ribose. Lokhu kuguqulwa kuyenza ibe yingxenye ebalulekile ye-DNA, lapho ihlangana khona ne-guanine ngesikhathi sokuhlanganiswa kwesisekelo. I-2′-Deoxycytidine idlala indima ebalulekile ekusetshenzisweni kwamaseli kanye nokwakheka kwe-DNA, isebenza njengesisekelo sokwakha i-deoxycytidine triphosphate (dCTP), ebalulekile ekuphindaphindweni nasekulungisweni kwe-DNA. Ngaphezu kwalokho, le nucleoside inemiphumela ebalulekile ocwaningweni lwebhayoloji yama-molecular, ekwelashweni komdlavuza, kanye namasu okulwa namagciwane, igcizelela ukubaluleka kwayo kokubili ocwaningweni oluyisisekelo kanye nezicelo zemitholampilo.
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I-2,2′-cyclouridine CAS:3736-77-4
I-2,2′-Cyclouridine iyi-bicyclic nucleoside derivative ye-uridine, ebonakala ngokwakhiwa kwesakhiwo esiyingqayizivele esijikelezayo esihilela izikhundla ze-2′ kanye ne-2” ze-ribose moiety. Lokhu kuguqulwa kwesakhiwo kunikeza izakhiwo ezihlukile ze-biochemical ezithinta ukuzinza kwayo kanye nomsebenzi webhayoloji. I-2,2′-Cyclouridine ithole isithakazelo ku-biology yamakhemikhali kanye ne-chemistry yezokwelapha ngenxa yezicelo zayo ezingaba khona njenge-antiviral agent kanye nocwaningo lwe-RNA. Amandla ayo okulawula ukusebenzisana kwe-nucleic acid kuyenza ibe ithuluzi eliwusizo lokufunda ubudlelwano besakhiwo se-RNA nomsebenzi, okungenzeka kuholele ekuthuthukisweni kwamasu okwelapha okuhloswe ngawo ukutheleleka ngamagciwane kanye nezifo zofuzo.
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2-Aminoadenosine CAS:2096-10-8
I-2-Aminoadenosine iyi-nucleoside derivative evela ngokwemvelo ye-adenosine, ehlukaniswa ngokuba khona kweqembu lama-amino endaweni engu-2 kashukela we-ribose. Lokhu kuguqulwa kushintsha kakhulu izakhiwo zayo ze-biochemical kanye nemisebenzi, okwenza ibe yi-molecule ebalulekile ezinqubweni ezahlukene zomzimba. I-2-Aminoadenosine ihilelekile ekusayineni kwamaseli, ekusetshenzisweni kwe-metabolism, nasezindleleni zokulawula, kufaka phakathi lezo ezihlobene ne-energy homeostasis kanye nokudluliselwa kwe-neurotransmission. Ukusetshenziswa kwayo okungenzeka kwezokwelapha kuhlanganisa amasimu amaningi, kufaka phakathi i-neurobiology kanye ne-cardiology, lapho ingathonya khona izimpendulo zamaseli ekucindezelekeni nasekulimaleni. Njengoba ucwaningo luqhubeka, i-2-aminoadenosine inesithembiso sokuthuthukisa ama-compounds amasha e-bioactive kanye nama-ejenti okwelapha.
