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I-Fludarabine Phosphate CAS: 75607-67-9
I-Fludarabine phosphate iyi-analog ye-adenosine eyenziwe nge-nucleoside, esetshenziswa kakhulu ekwelapheni izifo ezibangelwa yigazi ezifana ne-chronic lymphocytic leukemia (CLL) kanye ne-non-Hodgkin lymphoma. Isebenza ngokuphazamisa ukwakheka nokulungiswa kwe-DNA, ekugcineni okuholela ekuqhekekeni kwamaseli omdlavuza ahlukanisa ngokushesha. Uma inikezwa ngemithambo yegazi noma ngomlomo, i-fludarabine phosphate ibonisa izakhiwo zokucindezela amasosha omzimba, okwenza isebenze ezimweni ezithile kodwa futhi idinga ukuqapha ngokucophelela imiphumela emibi. Ukwethulwa kwayo kumele intuthuko ebalulekile ku-chemotherapy, inikeza indlela eqondiwe eye yathuthukisa imiphumela yeziguli eziningi ezinomdlavuza wegazi othize.
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i-o-Toluic acid CAS:118-90-1
I-o-Toluic acid, eyaziwa nangokuthi i-ortho-toluic acid, iyi-aromatic carboxylic acid enefomula yama-molecule C₈H₈O₂. Iqukethe iqembu le-methyl kanye neqembu le-carboxylic acid elixhunywe kuma-athomu e-carbon aseduze endandatho ye-benzene, enikeza izakhiwo zamakhemikhali ezihlukile kanye nokusabela. Le khompawundi ikhona njengesiqina esingenambala futhi iyancibilika ezinyibilikeni eziphilayo. I-o-Toluic acid isebenza njengomxhumanisi obalulekile ekwakhiweni kwamakhemikhali ahlukahlukene, kufaka phakathi udayi, imithi, kanye namakhemikhali ezolimo. Isakhiwo sayo esiyingqayizivele namaqembu asebenzayo enza kube lula ukusabela okuningi, okwenza kube wusizo kokubili ezindaweni zezimboni kanye nelebhu.
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I-Glycinonitrile hydrochloride CAS: 6011-14-9
I-Glycinonitrile hydrochloride iyinhlanganisela yamakhemikhali enefomula yama-molecule i-C₂H₄ClN₃, equkethe i-glycine derivative ehlanganisa iqembu elisebenzayo le-nitrile. Le kristalu eqinile emhlophe yaziwa ngokusetshenziswa kwayo okungenzeka ekwakhiweni kwezinto eziphilayo kanye namakhemikhali ezokwelapha. I-Glycinonitrile ingasebenza njengesakhiwo esiguquguqukayo ekwakhiweni kwama-molecule ahlukahlukene asebenzayo ngokwezinto eziphilayo, okuhlanganisa imithi kanye namakhemikhali ezolimo. Izakhiwo zayo eziyingqayizivele ziyenza ibe yikhambi elikhangayo locwaningo olwengeziwe kanye nentuthuko, ikakhulukazi ekwakhiweni kwama-compounds anemisebenzi ethile yezokwelapha.
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I-Vinylene carbonate CAS:872-36-6
I-Vinylene carbonate (VC) iyinhlanganisela ye-cyclic carbonate enefomula yama-molecule C₃H₄O₃. Ibonakala ngeqembu layo le-vinyl kanye neqembu elisebenzayo le-carbonyl, okwenza ibe yi-monomer esabela kakhulu kumakhemikhali e-organic. I-VC isetshenziswa kakhulu njengesengezo se-electrolyte kumabhethri e-lithium-ion, lapho ithuthukisa khona ukwakheka kwe-solid solid electrolyte interphase (SEI), ithuthukisa ukusebenza kwebhethri kanye nokuphila kwayo. Ngaphezu kwalokho, i-vinylene carbonate isebenza njengebhloko yokwakha ama-polymerization ahlukahlukene kanye nokuhlanganiswa kwamakhemikhali, igcizelela kakhulu ukubaluleka kwayo kwisayensi yezinto zokwakha kanye nokuhlanganiswa kwezinto eziphilayo.
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I-Disodium 5′-Guanylate CAS: 5550-12-9
I-Disodium 5′-guanylate, evame ukubizwa ngokuthi i-GMP, iyi-nucleotide derivative edlala indima ebalulekile ezinqubweni ezahlukene ze-biochemical ngaphakathi kwezinto eziphilayo. Njengesengezo sokudla kanye nesithuthukisi se-flavour, ivame ukusetshenziswa kanye ne-monosodium glutamate (MSG) ukuthuthukisa ukunambitheka kwe-umami ekusetshenzisweni kokupheka. I-GMP isebenza njenge-molecule yokubonisa ehilelekile ekuxhumaneni kwamaseli kanye nokulawulwa kwe-metabolic, ithonya izinqubo ezifana nokuhlanganiswa kwamaprotheni kanye ne-energy metabolism. Ngaphezu kwalokho, isetshenziswa ocwaningweni lwe-molecular biology njenge-substrate kanye ne-activator yezimpendulo ezahlukahlukene ze-enzyme, igcizelela ukubaluleka kwayo ngale kwendima yayo ekuthuthukisweni kwe-flavour.
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i-p-Toluic acid CAS:99-94-5
I-p-Toluic acid, eyaziwa nangokuthi i-para-toluic acid, iyi-aromatic carboxylic acid enefomula yama-molecule C₈H₈O₂. Iqukethe i-toluene derivative lapho iqembu le-carboxyl (-COOH) kanye neqembu le-methyl (-CH₃) zibekwe ezinhlangothini eziphambene zendandatho ye-benzene. Lokhu kuhlelwa kwesakhiwo kunikeza izakhiwo zamakhemikhali ezihlukile kanye nokusabela. I-p-Toluic acid ibonakala njenge-crystalline solid emhlophe futhi iyancibilika ezinyibilikisweni eziphilayo. Isebenza njenge-intermediate ebalulekile ekuhlanganisweni kwamakhemikhali ahlukahlukene, kufaka phakathi amadayi, imithi, kanye namakhemikhali ezolimo, ikhombisa ukuguquguquka kwayo kanye nokubaluleka kwayo kokubili ekusetshenzisweni kwezimboni kanye naselabhorethri.
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I-N,N'-Diaminoguanidine monohydrochloride CAS:36062-19-8
I-N,N'-Diaminoguanidine monohydrochloride (DGH) iyinhlanganisela yezinto eziphilayo enefomula i-C₂H₈ClN₄, equkethe i-guanidine derivative enamaqembu amabili e-amine. Leli khemikhali eliguquguqukayo lisetshenziswa kakhulu ekusetshenzisweni kwemithi, ikakhulukazi njengesandulela ekwakhiweni kwama-molecule ahlukahlukene asebenzayo kanye nemithi. I-DGH idonsele ukunaka ngezakhiwo zayo zokwelapha ezingaba khona, okuhlanganisa nokusetshenziswa ekwelapheni izimo ezithile zezokwelapha ezifana nesifo sikashukela kanye nezifo zokuphefumula. Isakhiwo sayo esiyingqayizivele siyivumela ukuthi ihlanganyele ekuphenduleni okubalulekile kwe-biochemical, okugqamisa ukubaluleka kwayo kumakhemikhali ezokwelapha kanye nokuthuthukiswa kwemithi.
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I-Capecitabine CAS:154361-50-9
I-Capecitabine umuthi we-chemotherapy osetshenziswa kakhulu ekwelapheni izinhlobo ezahlukene zomdlavuza, okuhlanganisa umdlavuza we-colorectal kanye nowebele. Ungumuthi oguqulwa ube uhlobo olusebenzayo, i-5-fluorouracil (5-FU), emzimbeni, osebenzisa imiphumela yawo yokulwa nomdlavuza ngokuvimbela ukwakheka kwe-DNA nokuphazamisa umsebenzi we-RNA emaseli ahlukanisa ngokushesha. I-Capecitabine ivame ukusetshenziswa kanye nezinye izidakamizwa zokwelapha ngamakhemikhali ukuze kuthuthukiswe ukusebenza kahle. Ukufakwa kwayo ngomlomo kunikeza enye indlela elula yokwelapha ngemithambo yegazi, kuthuthukiswe ukunamathela kwesiguli. Nakuba ngokuvamile ibekezelelwa kahle, i-capecitabine ingabangela imiphumela emibi njenge-hand-foot syndrome, isicanucanu, kanye ne-myelosuppression.
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4(1H)-Pyrimidinone,5-fluoro-2-methoxy-,hydrazone CAS:166524-64-7
I-4(1H)-Pyrimidinone, 5-fluoro-2-methoxy-, i-hydrazone iyinhlanganisela ekhethekile yezinto eziphilayo ebonakala ngokuba khona kwendandatho ye-pyrimidinone kanye nokusebenza kwe-hydrazone. Ngefomula yama-molecule C₉H₁₀FN₃O₂, le nhlanganisela ifaka i-athomu ye-fluorine kanye neqembu le-methoxy elifaka isandla ezimpahleni zalo zamakhemikhali ezihlukile. Ama-Hydrazone aziwa ngokusebenza kwawo kanye nokusebenza kwawo ezinhlelweni ezahlukahlukene zokwenziwa kwezinto eziphilayo. Ngenxa yesakhiwo sawo, le nhlanganisela inemiphumela engaba khona kumakhemikhali ezokwelapha, ikakhulukazi njengesandulelo noma esiphakathi ekuthuthukisweni kwama-molecule asebenzayo anokubaluleka kokwelapha.
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I-3-Methylsalicylic acid CAS: 83-40-9
I-3-Methylsalicylic acid, eyaziwa nangokuthi i-3-(methyl)salicylic acid noma i-3-methyl-2-hydroxybenzoic acid, iyinhlanganisela enuka kamnandi enefomula yama-molecule i-C₈H₈O₃. Iqukethe iqembu le-hydroxyl (-OH) kanye neqembu le-carboxylic acid (-COOH) elinamathiselwe endandatho ye-benzene, kanye neqembu le-methyl elibekwe i-meta eqenjini le-hydroxyl. Lokhu kuhlelwa kwesakhiwo kunikeza izakhiwo zamakhemikhali ezihlukile ezenza kube usizo ezinhlotsheni ezahlukahlukene. I-3-Methylsalicylic acid isetshenziswa ekwakhiweni kwezinto eziphilayo, emithini yemithi, kanye nasekwakheni ezinye izinto ezihlanganisiwe. Imisebenzi yayo engaba khona yezinto eziphilayo iqokomisa ukubaluleka kwayo kumakhemikhali okwelapha kanye nocwaningo.
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(+)-5-Iodo-2′-deoxyuridine CAS:54-42-2
(+)-5-Iodo-2′-deoxyuridine (IUdR) iyi-analog ye-nucleoside yokwenziwa ye-deoxyuridine, ehlanganisa i-athomu ye-iodine endaweni engu-5 yendandatho ye-uracil. Njenge-ejenti yokulwa namagciwane kanye nomdlavuza, i-IUdR iye yacwaningwa ngekhono layo lokuvimbela ukwakheka kwe-DNA kumaseli ahlukanisa ngokushesha, okwenza ibe usizo kakhulu ocwaningweni lomdlavuza kanye namasu okwelapha. Isebenza ngokuphazamisa inqubo evamile yokuphindaphinda kwe-DNA, okuholela ekufeni kwamaseli ezicutshini ze-neoplastic. Ngaphezu kwalokho, i-IUdR isetshenziswa ekwelashweni okuhlukahlukene kokuhlola, okuhlanganisa i-brachytherapy yomdlavuza wendawo, ngenxa yokusebenza kwayo ekuqondiseni amaseli esimila ngokukhetha.
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![2-Azabicyclo[2.2.1]hept-5-en-3-one CAS:49805-30-3](https://cdn.globalso.com/xindaobiotech/VYH6FUCIIBE_I7B6OOPY333.png)
2-Azabicyclo[2.2.1]hept-5-en-3-one CAS:49805-30-3
I-2-Azabicyclo[2.2.1]hept-5-en-3-one iyinhlanganisela yezinto eziphilayo e-bicyclic ebonakala nge-athomu ye-nitrogen ngaphakathi kwesakhiwo sayo sendandatho kanye neqembu elisebenzayo le-ketone. Ngefomula yama-molecule i-C₇H₉NO, le nhlanganisela ingeyesigaba samakhemikhali e-azabicyclic athole isithakazelo ekuhlanganisweni kwezinto eziphilayo kanye ne-chemistry yezokwelapha. Isakhiwo sayo esiyingqayizivele sinikeza izakhiwo zamakhemikhali ezithakazelisayo, okwenza kube yindawo ebalulekile ekwakhiweni kwama-molecule ahlukahlukene asebenzayo. Ucwaningo ngezicelo zalo ezingaba khona luhlanganisa imithi kanye namakhemikhali ezolimo, lapho isebenza khona njengesandulela sokuthuthukisa amakhemikhali anokubaluleka kokwelapha.
