I-Candesartana Cilexetila CAS:145040-37-5

I-Candesartan cilexetil iyisidakamizwa esikhiqizwa yi-angiotensin II receptor antagonist enamandla, esebenza isikhathi eside, futhi ekhethayo, i-candesartan. Ishiswa ngokushesha ibe yi-candesartan ngesikhathi sokumuncwa kwamathumbu. Ngemva kokushiswa kwe-candesartan cilexetil ibe yi-candesartan ngesikhathi sokumuncwa kwamathumbu, i-candesartan incintisana ngokukhetha ne-angiotensin II ukuze ibophe i-angiotensin II receptor subtype 1 AT1 emisipheni ebushelelezi yemithambo yegazi, ivimbele ukuvaleka kwemithambo yegazi okubangelwa yi-angiotensin II futhi ibangele ukuvaleka kwemithambo yegazi. Ngaphezu kwalokho, ukuphikiswa kwe-AT1 endlaleni ye-adrenal kuvimbela ukwakheka kwe-aldosterone evuselelwe yi-angiotensin II kanye nokukhiqizwa kwayo yi-adrenal cortex; ukukhishwa kwe-sodium namanzi kuyanda, kulandelwe ukwehla kwevolumu ye-plasma kanye nomfutho wegazi.