I-Candesartan CAS:139481-59-7 Umhlinzeki Womkhiqizi Isithombe Esivelele

Umhlinzeki Womkhiqizi weCandesartan CAS:139481-59-7

I-Candesartan iyi-angiotensin II receptor I (AT1) antagonist, i-IC50s=1.12 kanye ne-2.86 nM ye-bovine adrenal cortex kanye ne-rabbit aorta ngokulandelana. Ivimbela ngokukhetha ukufinyela okubangelwa yi-angiotensin II kwemigqa ye-rabbit aortic ngaphandle kokuthinta ukufinyela okubangelwa ezinye izinto ezifana ne-norepinephrine, i-KCl, i-serotonin, i-PGF2α noma i-endothelin.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

I-Candesartan iyi-antagonist ekhethiwe ye-AT1 (i-angiotensin II receptor 1). Ukuchasana kwama-angiotensin receptors kuvimbela ukuvaleka kwemithambo yegazi kanye nokukhiqizwa kwe-aldosterone, okuholela ekunciphiseni kokuhlushwa kwamanzi kanye ne-sodium egazini. Ibonisa imiphumela yokulwa nomfutho wegazi ophezulu kumamodeli ezilwane. Isetshenziswa ekwelapheni ukwehluleka kwenhliziyo okuvalekile, njenge-antihypertensive. I-Candesartan ayithinti ukusebenza noma ukwanda kwamaseli kodwa ikhulisa ukuvezwa kwe-VEGF kanye ne-interleukin-8 endaweni ekhuliswe amaseli e-KU-19-19. I-Candesartan (0.1 nM) inganciphisa impendulo enkulu yokuvaleka kwemithambo yegazi ku-angiostensin II cishe ngo-50%.

Isampula Yomkhiqizo

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C24H20N6O3
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe
Inombolo ye-CAS	139481-59-7
Ukupakisha	1KG 25KG
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.