Umhlinzeki Womkhiqizi we-Simvastatin CAS:79902-63-9

I-Simvastatin iyi-semi-synthetic, i-hydrophobic kancane, ifana ne-lovastatin. Njenge-lovastatin, i-simvastatin iyisithiyo esithile se-HMG-CoA reductase futhi isetshenziswa ngokwezokwelapha ukunciphisa i-LDL cholesterol. Muva nje, ama-statin abe yizivivinyo ezibalulekile ze-biochemical ku-biology yamaseli. Ukubandakanyeka kwawo ezigamekweni eziningi kungahlotshaniswa nendlela yawo eyinhloko yokusebenza, noma kunjalo, indlela yokusebenza kweminye imiphumela eminingi ayibonakali kangako. I-Simvastatin iyisithiyo esithile se-HMG-CoA reductase, i-enzyme ekhuthaza ukuguqulwa kwe-HMG-CoA ibe yi-mevalonate, isinyathelo sokuqala se-cholesterol biosynthesis. Isetshenziswa ekwelapheni i-hypercholesterolemia, njengoba yehlisa amazinga ama-lipoprotein aphansi kanye nama-triglycerides, futhi iphakamisa amazinga e-lipoprotein aphezulu.