I-PhentolamineMesylate CAS:65-28-1

I-Phentolamine mesylate isebenza izindima ezibalulekile ekwelashweni nasekusetshenzisweni kocwaningo. Njenge-vasodilator enamandla kanye ne-antihypertensive agent, isetshenziswa ekwelapheni izimo eziphuthumayo ze-hypertension, ikakhulukazi ezimweni zenkinga ye-pheochromocytoma, lapho ukwehla komfutho wegazi ngokushesha kubalulekile khona. Iphinde ithole usizo ekuphatheni iziqephu ze-hypertension ezibangelwa yi-iatrogenic catecholamine ngesikhathi sokuhlinzwa kanye nezinye izindlela zokungenelela kwezokwelapha. Kwezokwelapha amazinyo, i-phentolamine mesylate isetshenziswa njenge-agent yokuguqula izinzwa yendawo, esiza ekuphathweni kwe-anesthesia yezicubu ezithambile ngemuva kwezinqubo zamazinyo ezibandakanya i-anesthetic yendawo equkethe i-vasoconstrictor njenge-epinephrine. Imiphumela yayo ye-vasodilating isiza ekunciphiseni ukuvinjelwa kokugeleza kwegazi kwendawo kanye nokusheshisa ukubuyiselwa kokugeleza kwegazi okuvamile kwezicubu. Ngaphezu kwalokho, le nhlanganisela isetshenziswa ezinqubweni zokuxilonga ezifana nokuvimbela nokwelapha i-dermal necrosis ebangelwa ukukhipha izidakamizwa ezisebenzayo, ukuqinisekisa ukugeleza kwegazi okufanele kwezicubu. Ngaphezu kwalokho, ihilelekile ezifundweni zocwaningo kanye nezivivinyo zemitholampilo ezihlola ukusetshenziswa kwayo okungenzeka ezimweni ezihlobene nokungasebenzi kahle kwemithambo yegazi, ukungasebenzi kahle kwe-erectile, kanye nesenzakalo sikaRaynaud, okufaka isandla ekuthuthukisweni kwezokwelapha zenhliziyo nemithambo yegazi. Indima ye-phentolamine mesylate ifinyelela ezindaweni zokuhlola njengethuluzi ocwaningweni lwezokwelapha kanye nolwezinto eziphilayo, isiza ekuphenyweni komsebenzi we-adrenergic receptor, izimpendulo zemithambo yegazi, kanye nokuguqulwa komsebenzi wesistimu yezinzwa enozwela. Amandla ayo okuvimba ama-adrenergic receptors kanye nomthelela emithanjeni yegazi kunegalelo ekuqondeni i-physiology yenhliziyo kanye nokuthuthukiswa kokungenelela kokwelapha okuqondiswe ezindleleni zokubonisa izimpawu ze-adrenergic. Sekukonke, ukusetshenziswa okuhlukahlukene kwe-phentolamine mesylate kugqamisa ukubaluleka kwayo kwezokwelapha, udokotela wamazinyo, ucwaningo, kanye nokuthuthukiswa kwemithi, kugcizelela amandla ayo okufaka isandla ekuphathweni okuphumelelayo kwezimo zenhliziyo kanye nokuthuthuka kolwazi lwesayensi oluhlobene nomsebenzi we-adrenergic receptor kanye nokulawulwa kwemithambo yegazi.