I-Letrozole iyingxenye yesizukulwane esisha se-aromatase inhibitors ekhethwa kakhulu futhi iwukuphuma kokwenziwa kwe-benzotriazole.I-Letrozole ivimbela i-aromatase ekunciphiseni amazinga e-estrogen, ngaleyo ndlela ivimbele i-estrogen ekukhuthazeni ukukhula kwesimila.Umsebenzi wayo we-vivo unamandla izikhathi ezingu-150-250 kunowesizukulwane sokuqala se-aromatase inhibitor i-Amarante.Njengoba ikhetha kakhulu, ngeke ithinte i-glucocorticoid, i-mineralocorticoid kanye nemisebenzi ye-thyroid;ngisho nangemithamo ephezulu, ngeke ibe nemiphumela evimbela ekukhiqizweni kwe-adrenal corticosteroid, inikeze inkomba ephezulu yokwelashwa.