I-H-His-OMe·2HCl CAS:7389-87-9

I-H-His-OMe·2HCl isebenza njengesakhiwo esibalulekile ekwakhiweni kwama-peptide, idlala indima ebalulekile ekwakheni ama-peptide anezici ezithile zesakhiwo nokusebenza. Ukuba khona kweqembu le-methyl ester kanye nosawoti we-hydrochloride kuqinisekisa ukuthi i-histidine residue ihlala ingashintshiwe ngesikhathi sezinqubo zokwenziwa kwama-peptide, okuvumela ukuhlanganiswa kwama-peptide okunembile nokulawulwayo. Le nhlanganisela iwusizo ekwakhiweni kwama-peptide anezakhiwo ezilungiselelwe njengokuqina okuthuthukisiwe, ukuncibilika, noma ukutholakala kwezinto eziphilayo, okwenza kube ithuluzi elibalulekile ekuthuthukisweni kwemithi, ikakhulukazi ekudaleni izidakamizwa ezisekelwe kuma-peptide ezinomphumela omuhle wokwelapha ngenxa yesimo sikasawoti. Ngaphezu kwendima yayo ekwakhiweni kwama-peptide, i-H-His-OMe·2HCl ithola ukusetshenziswa ocwaningweni lwe-proteomics kanye ne-biochemical, lapho ingasetshenziswa khona ukutadisha ukusebenzisana kwama-protein nama-protein, ukuphenya imisebenzi ye-enzyme, nokuhlola amandla okugoqa ama-protein. Isakhiwo sayo esilungiselelwe sivumela abacwaningi ukuthi bahlole ubunzima bezinqubo zamaseli kanye nezindlela zezifo, okufaka isandla ekuthuthukisweni kokuqonda impilo kanye ne-pathology. Ukuguquguquka kanye nokuhambisana kwale nhlanganisela nezimo ezahlukahlukene zokuhlola kwenza kube yingxenye ebalulekile yokwembula ubunzima bezinhlelo zezinto eziphilayo kanye nokuthuthukisa ukungenelela okuqondiswe ezimweni ezahlukene zezokwelapha. Ngamafuphi, i-H-His-OMe·2HCl imele ithuluzi eliwusizo kubacwaningi ekuhlanganisweni kwama-peptide, ekuthuthukisweni kwemithi, kanye nasezifundweni ze-biochemical, enikeza ikhono lokulungisa ama-peptide anezakhiwo ezithile futhi ahlukanise izindlela eziyisisekelo zezinqubo zezinto eziphilayo, ngaleyo ndlela inikele ekuthuthukisweni kwezokwelapha kanye ne-biotechnology.