H-Gly-OBzl·Tos CAS:1738-76-7

I-H-Gly-OBzl·Tos idlala indima ebalulekile ekwakhiweni kwe-peptide, isebenza njengesisekelo esiyinhloko sokwakha ama-peptide anezici ezithile zesakhiwo nokusebenza. Iqembu le-benzyl ester kanye neqembu elivikela i-tosyl liqinisekisa ukuthi i-glycine residue ihlala ingashintshiwe ngesikhathi sezinqubo zokwenziwa kwe-peptide, okuvumela ukuhlanganiswa kwe-peptide okunembile nokulawulwayo. Le nhlanganisela iwusizo ekwakhiweni kwama-peptide anezakhiwo ezilungiselelwe njengokuqina okuthuthukisiwe, ukutholakala kwe-bioavailability, noma ukumelana nokuwohloka kwe-enzyme, okwenza kube ithuluzi elibalulekile ekuthuthukisweni kwemithi, ikakhulukazi ekudaleni izidakamizwa ezisekelwe ku-peptide. Ngaphezu kwendima yayo ekwakhiweni kwe-peptide, i-H-Gly-OBzl·Tos ithola ukusetshenziswa ocwaningweni lwe-proteomics kanye ne-biochemical, lapho ingasetshenziswa khona ukutadisha ukusebenzisana kwamaprotheni nama-protein, ukuphenya umsebenzi we-enzyme, nokuhlola amandla okugoqa amaprotheni. Isakhiwo sayo esilungiselelwe sivumela abacwaningi ukuthi bahlole ubunzima bezinqubo zamaseli kanye nezindlela zezifo, okufaka isandla ekuthuthukisweni kokuqonda impilo kanye ne-pathology. Ukuguquguquka kanye nokuhambisana kwale nhlanganisela nezimo ezahlukahlukene zokuhlola kwenza kube yingxenye ebalulekile yokwembula ubunzima bezinhlelo zezinto eziphilayo kanye nokuthuthukisa ukungenelela okuqondiswe ezimweni ezahlukene zezokwelapha. Ngamafuphi, i-H-Gly-OBzl·Tos imelela ithuluzi eliwusizo kubacwaningi ekuhlanganisweni kwama-peptide, ekuthuthukisweni kwemithi, nasezifundweni ze-biochemical, enikeza ikhono lokulungisa ama-peptide anezakhiwo ezithile futhi ihlukanise izindlela eziyisisekelo zezinqubo zezinto eziphilayo, ngaleyo ndlela inikele ekuthuthukisweni kwezokwelapha kanye ne-biotechnology.