I-Fmoc-Glu(OBzl)-OH CAS:123639-61-2

I-Fmoc-Glu(OBzl)-OH isebenza njengethuluzi eliguquguqukayo ekuhlanganisweni kwe-peptide, ikakhulukazi ekwakheni ama-peptide aqukethe i-glutamic acid ngokunemba. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwe-peptide, kuyilapho iqembu le-benzyl lengeza ungqimba olwengeziwe lokuvikela eqenjini le-carboxyl. Abacwaningi basebenzisa kakhulu i-Fmoc-Glu(OBzl)-OH ekwakhiweni kwama-peptide ngezinhlelo ezahlukahlukene, okuhlanganisa ukuthuthukiswa kwemithi, izinto eziphilayo, kanye nokuklama ama-peptide asebenzayo anezici ezithile zesakhiwo. Ukuhambisana kwayo nezindlela ezijwayelekile zokwenziwa kwe-peptide, kokubili kumasu esigaba esiqinile kanye nesigaba sesisombululo, kuthuthukisa ukuguquguquka kwayo emizamweni yocwaningo ehlukahlukene. Ukususwa okulawulwayo kwamaqembu avikelayo kuvumela ukufakwa kwe-glutamic acid ngamasu okulandelana kwe-peptide, kwandise ububanzi bama-peptide angenziwa. Ngaphezu kwalokho, i-Fmoc-Glu(OBzl)-OH ithola usizo ekutadisheni izinqubo zamaseli, ukwakheka kwe-neuropeptide, kanye nokuthuthukiswa kwezokwelapha ezisekelwe ku-peptide. Ukusetshenziswa okunesu kweqembu lokuvikela i-benzyl kwenza kube lula ukuphathwa ngendlela enembile kwe-glutamic acid reactivity, okunikeza abacwaningi ithuluzi eliwusizo lokuklama ama-peptide anezinguquko ezenziwe ngokwezifiso. Ngamafuphi, i-Fmoc-Glu(OBzl)-OH imele njengethuluzi eliyisisekelo nelibalulekile kumakhemikhali e-peptide, inika abacwaningi amandla okuhlola nokuguqula i-glutamic acid reactivity yezinhlelo zokusebenza eziningi zesayensi, ikakhulukazi ukugxila kuma-peptide aqukethe le amino acid ebalulekile.