I-Fmoc-D-Asn-OH CAS:108321-39-7

I-Fmoc-D-Asn-OH iyisidlali esibalulekile ekuhlanganisweni kwama-peptide, ikakhulukazi ekuhlanganisweni okulawulwayo kwama-peptide aqukethe i-D-enantiomer ye-asparagine. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwama-peptide. Le nhlanganisela isetshenziswa kakhulu ekuhlanganisweni kwama-peptide ezifundweni zezinto eziphilayo, ekuthuthukisweni kwemithi, kanye nasekuklanyweni kwama-peptide asebenzayo anezilungiselelo ezithile ze-stereochemical. Ukuguquguquka kwe-Fmoc-D-Asn-OH kudlulela ekusetshenzisweni kwayo ekwakheni ama-peptide anezinsalela ze-D-asparagine, okufaka isandla ekuthuthukisweni kwama-peptide anezakhiwo nemisebenzi elungiselelwe. Abacwaningi basebenzisa ukuhambisana kwayo nezindlela ezijwayelekile zokwenziwa kwama-peptide, beyisebenzisa kumasu ahlukahlukene okwenziwa kwama-peptide. Ukuqina kwayo kanye nokulula kokuphathwa kwayo kwenza kube ukukhetha okuthandwayo kokukhiqiza ama-peptide anezinguquko eziqondile, ikakhulukazi lezo ezihilela ama-D-amino acid. Ngaphezu kwalokho, i-Fmoc-D-Asn-OH ithola usizo ekuhlanganisweni kwama-peptide ezinto eziphilayo, ucwaningo lwe-proteomics, kanye nokutadisha izinqubo zamaseli, lapho ukufakwa kwama-D-amino acid kunganikeza izakhiwo ezihlukile. Ukususwa kokuvikelwa okulawulwayo kweqembu le-Fmoc kuvumela ukufakwa kwe-D-asparagine ngamasu okulandelana kwama-peptide. Ngamafuphi, i-Fmoc-D-Asn-OH imele njengethuluzi eliguquguqukayo nelibalulekile kumakhemikhali e-peptide, ithuthukisa ucwaningo kanye nezinhlelo zokusebenza emikhakheni eyahlukene yesayensi ngokugxila kuma-peptide aqukethe i-D-amino acid.