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I-N-(2-Chloro-4-hydroxyphenyl)-N'-cyclopropyl-urea CAS:796848-79-8
N-(2-Chloro-4-hydroxyphenyl)-N'-cyclopropyl-urea iyinhlanganisela yamakhemikhali enefomula yama-molecule C10H11ClN2O2. Ingokwesigaba sezinto ezivela ku-urea ezithathelwe indawo yiqembu le-chloro-hydroxyphenyl kanye neqembu le-cyclopropyl. Le nhlanganisela iyaziwa ngobunzima bayo besakhiwo kanye nokusetshenziswa kwayo okungenzeka ezifundweni ezahlukahlukene zamakhemikhali nezebhayoloji.
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1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic acid methyl ester CAS:205448-65-3
I-1,4-Dihydro-7-methoxy-4-oxo-6-quinolinei-carboxylic acid i-methyl ester iyinhlanganisela yamakhemikhali enefomula yama-molecule i-C12H11NO4. Ingokwesigaba sama-compounds e-quinoline futhi ichazwa yiqembu le-methyl ester elinamathiselwe endandatho ye-quinoline, eline-methoxy esikhundleni sendawo 7 kanye neqembu le-keto esikhundleni 4.
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I-AZD-9291 mesylate CAS:1421373-66-1
I-AZD-9291 mesylate iyinhlanganisela yemithi enefomula yama-molecule C28H33N7O4∙CH4O3S. Ingesigaba sama-tyrosine kinase inhibitors futhi isetshenziswa kakhulu ekwelapheni umdlavuza wamaphaphu ongewona amancane (i-NSCLC). Lo muthi uhlasela futhi uvimbele ngokukhetha izinhlobo eziguquliwe ze-epidermal growth factor receptor (EGFR), ezivame ukutholakala ezimila ze-NSCLC.
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5-Chloromethyl-2H-1,2,4-triazolin-3-one CAS:252742-72-6
I-5-Chloromethyl-2H-1,2,4-triazolin-3-one iyinhlanganisela ebalulekile yamakhemikhali enezinhlelo zokusebenza ezihlukahlukene kumakhemikhali ezokwelapha kanye nocwaningo lwezolimo. Iyingxenye yesigaba sezinto ezisuselwa ku-triazolinone, ezihlukaniswa ngesakhiwo samangqamuzana esiyingqayizivele esifaka isandla emisebenzini yayo yezinto eziphilayo kanye nokusetshenziswa okungenzeka kokwelapha.
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I-5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE CAS:42518-98-9
I-5-Chlorothiophene-2-carbonyl chloride iyinhlanganisela yamakhemikhali eyingxenye yesigaba sama-thienylacyl chloride. Ibonakala ngesakhiwo sayo sama-molecule esakhiwe yindandatho ye-thiophene ethathelwe indawo yiqembu le-chloro endaweni engu-5 kanye neqembu le-carbonyl chloride endaweni engu-2. Le nhlanganisela inentshisekelo enkulu ekuhlanganisweni kwezinto eziphilayo ngenxa yokusabela kwayo okuhlukahlukene kanye nezicelo ezingaba khona kwisayensi yemithi nezinto zokwakha.
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5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone CAS:503615-03-0
I-5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone iyinhlanganisela yamakhemikhali eyaziwa ngesakhiwo sayo esiyinkimbinkimbi sama-molecule kanye nezicelo ezahlukahlukene kumakhemikhali ezokwelapha kanye nocwaningo lwemithi. Le nhlanganisela ingeyesigaba sama-pyridinones futhi ihlukaniswa ngokuhleleka kwayo okuhlukile kwamaqembu asebenzayo, anikeza izakhiwo ezithile ezibalulekile emisebenzini yayo yezinto eziphilayo.
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I-4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester CAS:5909-24-0
I-4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid i-ethyl ester iyinhlanganisela yamakhemikhali eyaziwa ngendima yayo ebalulekile kumakhemikhali ezokwelapha kanye nocwaningo lwemithi. Njengoba iyingxenye yesigaba sezinto ezisuselwa ku-pyrimidine, le nhlanganisela ibonisa isakhiwo esihlukile sama-molecule esibalulekile emisebenzini yayo yezinto eziphilayo kanye nezicelo zokwelapha.
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I-3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE CAS:41965-95-1
I-3-Chloro-4-Methoxybenzylamine I-Hydrochloride iyinhlanganisela yamakhemikhali ephawulekayo eyaziwa kabanzi ngokusetshenziswa kwayo kumakhemikhali ezokwelapha kanye nocwaningo lwemithi. Le nhlanganisela ingena esigabeni sama-aromatic amines futhi ihlukaniswa ngokuhleleka kwayo okuqondile kwamaqembu asebenzayo abalulekile emisebenzini yayo yezinto eziphilayo.
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3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one CAS:545445-44-1
I-3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one iyinhlanganisela yamakhemikhali eyaziwa ngesakhiwo sayo esiyinkimbinkimbi sama-molecule kanye nezicelo ezahlukahlukene kumakhemikhali ezokwelapha kanye nokuthuthukiswa kwemithi. Le nhlanganisela ingeyesigaba sama-dihydropyridinones futhi ibonakala ngokuhleleka kwayo okuyinkimbinkimbi kwamaqembu asebenzayo, okunikeza izakhiwo ezithile ezibalulekile emisebenzini yayo yezinto eziphilayo.
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I-L(-)-Thiazolidine-4-carboxylic acid I-CAS:34592-47-7
I-L(-)-Thiazolidine-4-carboxylic acid iyinhlanganisela yamakhemikhali ephawulekayo eyaziwa ngokusetshenziswa kwayo okuhlukahlukene kumakhemikhali ezokwelapha kanye nocwaningo lwemithi. Njengoba iyingxenye yezinhlobo ze-thiazolidine derivatives, le nhlanganisela inesakhiwo esihlukile sama-molecule esibalulekile emisebenzini yayo yezinto eziphilayo kanye namandla okwelapha.
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I-Nintendonib CAS:656247-17-5
I-Nintedanib iyi-molecule encane enamandla i-tyrosine kinase inhibitor (TKI) ebaluleke kakhulu kwezokwelapha ezifweni ze-oncology kanye nezifo ze-fibrotic. Isebenzisa imiphumela yayo yezokwelapha ngokugxila kuma-receptor amaningi e-tyrosine kinases ahilelekile ku-angiogenesis, i-fibrogenesis, kanye nokulawulwa kokukhula kwesimila.
