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I-CAS ye-Lasmiditant:439239-90-4
I-Lasmiditan, ethengiswa ngaphansi kwegama lomkhiqizo i-Reyvow, iyinhlanganisela entsha yemithi eyenzelwe ukunciphisa ukuhlaselwa yi-migraine okukhulu kubantu abadala. Ingaphansi kwesigaba sama-agonists akhethiwe e-serotonin receptor, ahlose ikakhulukazi uhlobo lwe-receptor lwe-5-HT1F. Le ndlela yokusebenza ihlukanisa i-Lasmiditan ekwelashweni kwe-migraine yendabuko, njengoba ingadali ukuminyana kwemithambo yegazi, okwenza ifaneleke ezigulini ezinezici eziyingozi zenhliziyo nemithambo yegazi.
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I-N-Methylcarbonyl-2-chloroacetamidrazone CAS:155742-64-6
I-N-Methylcarbonyl-2-chloroacetamidrazone iyinhlanganisela yamakhemikhali eyaziwa ngokusetshenziswa kwayo okuhlukahlukene ekuhlanganisweni kwezinto eziphilayo kanye namakhemikhali okuhlanganisa. Ukuhlanganiswa kwayo kuhilela ukusabela kwe-N-methylcarbamoyl chloride ne-2-chloroacetohydrazide, okuholela ekwakhekeni okunezakhiwo ezihlukile zesakhiwo nokusebenza. Le nhlanganisela ibonakala ngekhono layo lokwakha ama-complexes ane-ion ehlukahlukene yensimbi, okwenza ibe yigugu ezifundweni zamakhemikhali okuhlanganisa. Ngaphezu kwalokho, amaqembu ayo e-carbonyl kanye ne-amidrazone anegalelo ekusebenzeni kwayo kanye nemisebenzi engaba khona yezokwelapha, okuyizindawo ezinesithakazelo socwaningo oluqhubekayo.
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I-Lasmiditan HCl CAS:613677-28-4
I-Lasmiditan hydrochloride (i-Lasmiditan HCl) iyinhlanganisela yemithi eyaziwa ngendima yayo ekwelapheni ukuhlaselwa yi-migraine okukhulu kubantu abadala. Yakhiwe njenge-agonist ekhethiwe ye-serotonin receptor, eqondiswe ngqo ku-5-HT1F receptor subtype, i-Lasmiditan HCl imele intuthuko ebalulekile ekwelapheni i-migraine ngenxa yendlela yayo eyingqayizivele yokusebenza kanye nokusebenza kahle kwezokwelapha.
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(6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone CAS:613678-03-8
I-(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone, eyaziwa nangokuthi i-aminopyridine methylpiperidone, iyinhlanganisela yamakhemikhali enemiphumela ebalulekile kumakhemikhali ezokwelapha kanye nocwaningo lwemithi. Njengoba yenziwe ngokuphendula kwe-6-aminopicolinic acid ne-1-methylpiperidin-4-one, le nhlanganisela ibonisa izici zesakhiwo ezihlukile ezifaka isandla emandleni ayo emithi kanye nokusebenza okuhlukahlukene.
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(S)-(+)-3-Quinuclidinol CAS:34583-34-1
(S)-(+)-3-I-Quinuclidinol, eyaziwa nangokuthi i-quinuclidinol, iyinhlanganisela ebalulekile kumakhemikhali ezinto eziphilayo kanye nocwaningo lwemithi ngenxa yokuhluka kwayo kwesakhiwo kanye nokusetshenziswa kwayo okuhlukahlukene. Le nhlanganisela ye-chiral itholakala ku-quinuclidine futhi ikhombisa izakhiwo zamakhemikhali nezemithi ezihlukile ezidonsele ukunaka emikhakheni eyahlukene yesayensi.
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I-APREPITANT INTERMEDIATES CAS:171482-05-6
Ama-intermediate e-Aprepitant adlala indima ebalulekile ekwakhiweni kwemithi kwe-aprepitant, i-neurokinin-1 (NK1) receptor antagonist enamandla esetshenziswa kakhulu ekuvimbeleni isicanucanu nokuhlanza okubangelwa yi-chemotherapy (CINV). Lawa ma-intermediate ayizingxenye ezibalulekile endleleni yokwenziwa enezinyathelo eziningi eholela ekwakhiweni kokugcina kwe-aprepitant. I-Aprepitant ngokwayo iyaziwa ngokusebenza kwayo kahle ekuphatheni i-CINV, inikeza impumuzo enkulu ezigulini ezithola ukwelashwa ngamakhemikhali. Ukwenziwa kwe-aprepitant kuhilela izinyathelo eziningana ezibalulekile, kanye nama-intermediate asebenza njengezitini zokwakha ezivumela ukukhiqizwa okuphumelelayo kwalesi sidakamizwa esibalulekile sokwelapha.
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2,4,6-TRIFLUOROBENZOYL CHLORIDE CAS:79538-29-7
I-2,4,6-Trifluorobenzoyl chloride, eyaziwa nangokuthi i-trifluorobenzoyl chloride, iyinhlanganisela yamakhemikhali ebalulekile ebaluleke kakhulu ngenxa yezicelo zayo ezihlukahlukene ekwakhiweni kwezinto eziphilayo kanye nezinqubo zezimboni. Njengoba yenziwe nge-chlorination ye-2,4,6-trifluorobenzoic acid, le nhlanganisela ibonisa izakhiwo zamakhemikhali ezihlukile ezifaka isandla ekusetshenzisweni kwayo kabanzi emikhakheni eyahlukahlukene.
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4-Chloro-6-iodoquinazoline CAS:98556-31-1
I-4-Chloro-6-iodoquinazoline iyinhlanganisela yamakhemikhali enefomula yama-molecule i-C9H5ClIN2. Ibonakala ngokuba khona kwama-athomu e-chlorine ne-iodine anamathele esakhiweni sendandatho ye-quinazoline. Le nhlanganisela isetshenziswa kakhulu ocwaningweni lwemithi kanye nokwakheka kwezinto eziphilayo ngenxa yezicelo zayo ezingaba khona ekuthuthukiseni imithi emisha kanye namanye ama-molecule asebenzayo ngokwezinto eziphilayo.
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(R)-3-Quinuclinol CAS:25333-42-0
(R)-3-I-Quinuclinol, eyaziwa nangokuthi i-quinuclidinol, iyinhlanganisela ebalulekile kumakhemikhali ezinto eziphilayo kanye nocwaningo lwemithi ngenxa yokuhluka kwayo kwesakhiwo kanye nokusetshenziswa kwayo okuhlukahlukene. Le nhlanganisela ye-chiral itholakala ku-quinuclidine futhi ikhombisa izakhiwo zamakhemikhali nezemithi ezihlukile ezidonsele ukunaka emikhakheni eyahlukene yesayensi.
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![(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT235.png)
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5
I-compound (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate iyi-molecule eyinkimbinkimbi yezinto eziphilayo enezici ezithile zesakhiwo kanye nezokwelapha. Ingokwesigaba sama-compound e-morpholine, avame ukusetshenziswa kumakhemikhali ezokwelapha ngenxa yemisebenzi yawo eyahlukahlukene yezinto eziphilayo.
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![(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0](https://cdn.globalso.com/xindaobiotech/1ZNB2ZF342ZWRNG304.png)
(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0
(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine iyinhlanganisela yamakhemikhali eyaziwa ngokusetshenziswa kwayo okuhlukahlukene ekuhlanganisweni kwezinto eziphilayo kanye namakhemikhali okwelapha. Njengoba yenziwe ngokuphendula kwe-(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone ene-ammonia noma i-amine, le nhlanganisela inezici zesakhiwo ezihlukile ezifaka isandla ekwahlukeni kwayo kokusebenza kanye nemisebenzi engaba khona yezokwelapha.
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(R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaI-CAS yami:608142-27-4
(R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine iyinhlanganisela yamakhemikhali eyaziwa ngezinhlelo zayo ezahlukahlukene ekuhlanganisweni kwezinto eziphilayo kanye namakhemikhali ezokwelapha. Njengoba yenziwe ngokuphendula kwe-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone ene-ammonia noma i-amine, le nhlanganisela ibonisa izici zesakhiwo ezihlukile ezifaka isandla ekusebenzeni kwayo okuhlukahlukene kanye nemisebenzi engaba khona yezokwelapha.
