Candesartana Cilexetila CAS:145040-37-5

I-Candesartan cilexetil iwumkhiqizo we-angiotensin II yohlobo 1 lwama-receptor antagonist anamandla, asebenza isikhathi eside, i-candesartan.I-hydrolyzed ngokushesha ibe yi-candesartan ngesikhathi sokumuncwa kwamathumbu.Ngemuva kwe-hydrolysis ye-candesartan cilexetil kuya ku-candesartan ngesikhathi sokumuncwa emathunjini, i-candesartan ikhetha ukuncintisana ne-angiotensin II ukuze kuboshwe i-angiotensin II receptor subtype 1 AT1 kumisipha ebushelelezi yemithambo, ivimbe i-angiotensin II-mediated vasoconstriction kanye nokwenza i-vasodilatation.Ngaphezu kwalokho, ukuphikiswa kwe-AT1 ku-adrenal gland kuvimbela ukwakheka kwe-aldosterone evuselelwe i-angiotensin II kanye nokukhiqizwa yi-adrenal cortex;ukwanda kwe-sodium namanzi, okulandelwa ukuncipha kwevolumu ye-plasma nomfutho wegazi.