I-Clascoterone CAS:19608-29-8 Umhlinzeki Womkhiqizi

I-Clascoterone ithuthukiswa njengokhilimu okhethekile yi-Cassiopea wezifo zesikhumba ezincike ku-androgen. I-Clascoterone (i-cortexolone 17α-propionate, i-CB-03-01) iyisitha esisha sama-receptor e-androgen. Ibopha kuma-receptor e-androgen ngokuhambisana okuphezulu. Ngokuncintisana nama-androgens ukuze ibophe kuma-receptor e-androgen, i-clascoterone isebenza ngokuvimbela ama-cascade okubonisa ama-receptor e-androgen akhuthaza i-acne pathogenesis, njengokwanda kwe-sebaceous gland, ukukhiqizwa kwe-sebum ngokweqile, kanye nezindlela zokuvuvukala. Ngo-Agasti 2020, i-FDA yavuma i-clascoterone yokwelashwa kokuqala kwe-acne (acne vulgaris) ezigulini zesilisa nabesifazane ezineminyaka engu-12 nangaphezulu. I-Clascoterone nayo iyaphenywa njengokwelashwa okusha kwe-androgenetic alopecia.