I-ZD-Pro-OH CAS:6404-31-5

I-ZD-Pro-OH isetshenziswa kakhulu kumakhemikhali e-peptide ekwakheni ama-peptide nama-peptidomimetics. Njenge-derivative ye-D-proline evikelwe yi-N-tert-butoxycarbonyl (Boc), yenza kube lula ukufakwa kwama-D-proline residues kuma-peptide chain, inikeze ukucushwa okuhlukile kwe-stereochemical okunezinhlelo zokusebenza ezingaba khona ekuthuthukiseni umsebenzi wezinto eziphilayo kanye nokuzinza kwe-metabolic. Osokhemisi nabacwaningi basebenzisa i-ZD-Pro-OH ekwakhiweni kwe-peptide yesigaba esiqinile kanye nesigaba sesisombululo ukuze kwethulwe ama-motif e-D-proline, okuvumela ukwakheka kwezakhiwo ezintsha ze-peptide zokusebenzisana okuqondiswe kuma-receptor ezinto eziphilayo nama-enzyme. Ngaphezu kwendima yayo ekwakhiweni kwe-peptide, i-ZD-Pro-OH ibalulekile ekuthuthukisweni kwama-peptidomimetics—ama-molecule aklanyelwe ukulingisa izakhiwo nemisebenzi yama-peptide asebenzayo. Ngokufaka izingxenye ezithathwe yi-ZD-Pro-OH, ososayensi bangahlola ukudalwa kwama-peptidomimetics ngamaphrofayili ahlukahlukene e-pharmacological, bevula indlela yabakhethiweyo bemithi emisha, ama-molecule probe, namathuluzi e-biochemical anezinhlelo zokusebenza zokwelapha nezocwaningo ezingaba khona. Ngaphezu kwalokho, i-ZD-Pro-OH isebenza njengengxenye ebalulekile ekukhiqizweni kwemithi yokwelapha esekwe ku-peptide. Ukuhlanzeka kwayo okuphezulu kanye nokuthembeka kwayo kuyenza ibe yinto ebalulekile ekukhiqizweni kwama-peptide enziwe ngokwezifiso kanye nama-peptidomimetics ezifundweni zangaphambi kokwelashwa kanye nezemitholampilo, okunikeza abacwaningi ukuguquguquka kokuklama izakhiwo zama-peptide ngamandla athuthukisiwe ezinto eziphilayo, ukukhetha, kanye nezakhiwo ze-pharmacokinetic. Sekukonke, i-ZD-Pro-OH idlala indima ebalulekile ekuthuthukisweni kwamasimu e-peptide chemistry, ukutholakala kwemithi, kanye nokuthuthukiswa kwemithi, inikeza ososayensi nabacwaningi amathuluzi okuvula amandla ama-peptide kanye nama-peptidomimetics okubhekana nezinselele eziyinkimbinkimbi zezinto eziphilayo kanye nokuthuthukisa ukusungula izinto ezintsha zokwelapha.

I-ZD-Pro-OH isetshenziswa kakhulu kumakhemikhali e-peptide ekwakheni ama-peptide nama-peptidomimetics. Njenge-derivative ye-D-proline evikelwe yi-N-tert-butoxycarbonyl (Boc), yenza kube lula ukufakwa kwama-D-proline residues kuma-peptide chain, inikeze ukucushwa okuhlukile kwe-stereochemical okunezinhlelo zokusebenza ezingaba khona ekuthuthukiseni umsebenzi wezinto eziphilayo kanye nokuzinza kwe-metabolic. Osokhemisi nabacwaningi basebenzisa i-ZD-Pro-OH ekwakhiweni kwe-peptide yesigaba esiqinile kanye nesigaba sesisombululo ukuze kwethulwe ama-motif e-D-proline, okuvumela ukwakheka kwezakhiwo ezintsha ze-peptide zokusebenzisana okuqondiswe kuma-receptor ezinto eziphilayo nama-enzyme. Ngaphezu kwendima yayo ekwakhiweni kwe-peptide, i-ZD-Pro-OH ibalulekile ekuthuthukisweni kwama-peptidomimetics—ama-molecule aklanyelwe ukulingisa izakhiwo nemisebenzi yama-peptide asebenzayo. Ngokufaka izingxenye ezithathwe yi-ZD-Pro-OH, ososayensi bangahlola ukudalwa kwama-peptidomimetics ngamaphrofayili ahlukahlukene e-pharmacological, bevula indlela yabakhethiweyo bemithi emisha, ama-molecule probe, namathuluzi e-biochemical anezinhlelo zokusebenza zokwelapha nezocwaningo ezingaba khona. Ngaphezu kwalokho, i-ZD-Pro-OH isebenza njengengxenye ebalulekile ekukhiqizweni kwemithi yokwelapha esekwe ku-peptide. Ukuhlanzeka kwayo okuphezulu kanye nokuthembeka kwayo kuyenza ibe yinto ebalulekile ekukhiqizweni kwama-peptide enziwe ngokwezifiso kanye nama-peptidomimetics ezifundweni zangaphambi kokwelashwa kanye nezemitholampilo, okunikeza abacwaningi ukuguquguquka kokuklama izakhiwo zama-peptide ngamandla athuthukisiwe ezinto eziphilayo, ukukhetha, kanye nezakhiwo ze-pharmacokinetic. Sekukonke, i-ZD-Pro-OH idlala indima ebalulekile ekuthuthukisweni kwamasimu e-peptide chemistry, ukutholakala kwemithi, kanye nokuthuthukiswa kwemithi, inikeza ososayensi nabacwaningi amathuluzi okuvula amandla ama-peptide kanye nama-peptidomimetics okubhekana nezinselele eziyinkimbinkimbi zezinto eziphilayo kanye nokuthuthukisa ukusungula izinto ezintsha zokwelapha.