I-Tos-Gly-OSu CAS:68385-26-2

I-Tos-Gly-OSu idlala indima ebalulekile ekwakhiweni kwe-peptide njenge-reagent ebalulekile yokusebenza kwamaqembu e-amino. Ukuba khona kweqembu le-tosyl kanye nokusebenza kwe-NHS kuvumela ukuthi kwenzeke ukusabela okukhethiwe kokuhlangana, okuvumela ukuhlanganiswa kwama-peptide aqukethe i-glycine namanye ama-molecule noma izindawo ngendlela elawulwayo. Le nhlanganisela iwusizo ekudaleni ama-peptide conjugates anezakhiwo ezithile njengokuqina okuthuthukisiwe, ukuncibilika, noma ikhono le-bioconjugation. Ekuthuthukisweni kwemithi, i-Tos-Gly-OSu ingasetshenziswa ukudala ama-peptide-drug conjugates, okungenzeka kuholele ekusebenzeni kahle kokwelapha okuthuthukisiwe, ukulethwa okuqondiwe, noma izinhlelo zokusebenza zokuxilonga. Ngaphezu kwendima yayo ekwakhiweni kwe-peptide, i-Tos-Gly-OSu ithola ukusetshenziswa ocwaningweni lwe-proteomics kanye ne-biochemical, lapho ingasetshenziswa khona ekuguqulweni kwamaprotheni endaweni ethile, ekwakhiweni kwemitapo yolwazi ye-peptide, noma ekusebenzeni kwezindawo zokuhlola ezahlukahlukene ze-bioanalytical. Ukuguquguquka kwayo kanye nokuhambisana kwayo nezimo ezahlukahlukene zokuhlola kwenza kube yingxenye ebalulekile yokwembula ubunzima bezinhlelo zezinto eziphilayo kanye nokuthuthukisa ukungenelela okuqondiwe kwezimo ezahlukene zezokwelapha. Ngamafuphi, i-Tos-Gly-OSu imele ithuluzi eliwusizo kubacwaningi ekuhlanganisweni kwama-peptide, ekuthuthukisweni kwemithi, nasezifundweni ze-biochemical, enikeza ikhono lokulungisa ama-peptide namaprotheni anezakhiwo ezithile kanye nokusebenza, ngaleyo ndlela inikele ekuthuthukisweni kwezokwelapha, ubuchwepheshe be-bio, kanye namasu okuhlanganisa i-bio.