I-Tofacitinib CAS:477600-75-2 Umhlinzeki Womkhiqizi

I-Tofacitinib iyi-inhibitor yokuqala encane ye-molecule kinase evunyelwe ukwelashwa kwe-RA. I-Tofacitinib iyi-inhibitor yezinhlobo ezine ze-Janus kinase (JAK): i-JAK1, i-JAK2, i-JAK3, kanye ne-Tyk2. I-Tofacitinib isebenza ngokuvimbela i-phosphorylation kanye nokusebenza kwe-signal transducers kanye ne-activators of transcription (STATs), ngaleyo ndlela icindezela ukukhiqizwa kwe-inflammatory mediators ezicutshini zamalunga.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

I-Tofacitinib iyisidakamizwa sokwelapha i-rheumatoid arthritis (RA), i-psoriasis, isifo samathumbu esivuvukalayo, nezinye izifo zomzimba, kanye nokuvimbela ukwenqatshwa kokufakelwa kwezitho. Iyisivimbeli se-enzyme i-Janus kinase 3 (JAK3), okusho ukuthi iphazamisa indlela yokubonisana ye-JAK-STAT edlulisela ulwazi ngaphandle kweseli kuyi-nucleus yeseli, ithonya ukuqoshwa kwe-DNA. Muva nje iboniswe kumodeli ye-murine ye-arthritis esungulwe, i-tofacitinib ithuthukisa ngokushesha isifo ngokuvimbela ukukhiqizwa kwabaxhumanisi bokuvuvukala nokucindezela izakhi zofuzo ezixhomeke ku-STAT1 ezicutshini zamalunga. Lokhu kusebenza kahle kule modeli yesifo kuhlobene nokuvinjelwa kwezindlela zokubonisana ze-JAK1 kanye ne-3, okuphakamisa ukuthi i-tofacitinib ingaba nenzuzo yokwelapha ngezindlela ezingezona kuphela ekuvimbeleni i-JAK3.

Isampula Yomkhiqizo

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C16H20N6O
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe qhwa
Inombolo ye-CAS	477600-75-2
Ukupakisha	25KG
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.