I-Spironolactone CAS:52-01-7 Umkhiqizi Umphakeli

I-Spironolactone (i-Aldactone) iyinhlanganisela eyasungulwa ekuqaleni njenge-mineralocorticoid antagonist futhi isetshenziswa njenge-diuretic ne-antihypertensive agent.Kodwa-ke, ngemithamo ephezulu i-spironolactone ibophezela kumamukeli we-androgen.Ekusebenzeni komtholampilo umphikisi we-androgen obuthakathaka osetshenziselwa ukwelapha i-hirsutism kwabesifazane ngokuvimbela ukubopha kwe-testosterone kuma-androgen receptors kuma-follicle ezinwele.Ukusetshenziswa kwe-spironolactone kwabesifazane ekwelapheni i-hirsutism noma impandla yesilisa kungabangela amazinga aphezulu e-serum potassium;lawa mazinga kufanele ahlolwe phakathi nenyanga ye-1 yokuqala imithi.I-Spironolactone (i-Aldactone) ihlobene nesakhiwo se-aldosterone futhi isebenza njenge-inhibitor yokuncintisana ukuvimbela ukuboshwa kwe-aldosterone kumaprotheni ayo okubopha amaselula.