Umhlinzeki Womkhiqizi we-Spironolactone CAS: 52-01-7

I-Spironolactone (Aldactone) iyinhlanganisela eyasungulwa ekuqaleni njengomphikisi we-mineralocorticoid futhi isetshenziswa njenge-ejenti yokukhipha isisu kanye ne-antihypertensive. Kodwa-ke, uma uthatha imithamo ephezulu, i-spironolactone ibopha kwi-androgen receptor. Emtholampilo, iyi-androgen antagonist ebuthakathaka esetshenziselwa ukwelapha i-hirsutism kwabesifazane ngokuvimbela ukubopha kwe-testosterone kuma-receptor e-androgen kuma-follicle ezinwele. Ukusetshenziswa kwe-spironolactone kwabesifazane ekwelapheni i-hirsutism noma i-pattern baldness yabesilisa kungabangela amazinga aphezulu e-potassium egazini; la mazinga kufanele ahlolwe zingakapheli inyanga eyodwa kusukela ekuqaleni komuthi. I-Spironolactone (Aldactone) ihlobene ngokwesakhiwo ne-aldosterone futhi isebenza njengesivimbeli sokuncintisana ukuvimbela ukubopha kwe-aldosterone kuphrotheni yayo ethile yokubopha amaseli.