I-R-(+)-alpha-Lipoic acid CAS:1200-22-2 Umhlinzeki Womkhiqizi

I-R-(+)-α-Lipoic acid iboniswe ukuthi ikhulisa kakhulu i-pyruvate oxidation ngenkathi isusa i-fatty acid oxidation kuma-hepatocytes egundane. Le miphumela yenza i-R-(+)-α-Lipoic acid ibe yindlela yokwelapha ethembisayo yokwelapha isifo sikashukela sohlobo lwesibili. Iyi-antioxidant yezinto eziphilayo enemisebenzi ye-prooxidant, amandla ayo okwelapha acwaningwa kabanzi, isib. ekwelapheni isifo i-Alzheimer's. I-α-Lipoic acid isetshenziswe njengendinganiso yokubhekisela ekuhlaziyweni kwe-α-lipoic acid ku-plasma yomuntu nge-high performance liquid chromatography ehlanganiswe ne-electron capture detector (HPLC-ECD), kuma-matrix ahlukahlukene okudla kanye nezithako zokudla yi-HPLC ehlanganiswe ne-coulometric electrode array detector (CEAD) kanye ne-electrospray ionization mass spectrometer (ESI-MS). Ingasetshenziswa njengendinganiso yokubhekisela ekunqumeni i-α-lipoic acid kumchamo womuntu nge-isocratic reversed-phase HPLC kanye nama-capsules e-α-lipoic acid yi-HPLC enokutholwa kwe-chemiluminescence.