Umhlinzeki Womkhiqizi we-Huperzine A 1 CAS:102518-79-6

I-Huperzine A umuthi omusha wokwelapha izinkinga zenkumbulo ezingengozini ongavimbela ngempumelelo i-cerebral neurasthenia kubantu abaneminyaka ephakathi nendawo kanye nabantu asebekhulile, ubuyisele umsebenzi wezinzwa ze-cranial, futhi usebenze ama-neurotransmitters e-cranial. I-Huperzine A ayikwazi nje ukuvimbela umsebenzi we-cholinesterase, kodwa futhi ithuthukise umsebenzi wokuqonda kanye nekhono lokufunda kanye nenkumbulo ngokusebenzisa izindlela ezahlukahlukene zezokwelapha njengokuthinta uhlelo lwama-free radicals, ukunciphisa amazinga okuvezwa kwe-somatostatin, i-intracellular [Ca2+], okuqukethwe kwe-glutamic acid kanye nokwandisa i-calmodulin (CaM) kanye ne-calmodulin messenger RNA (CaM mRNA). I-Huperzine A iyi-ejenti yokwelapha engaba khona yesifo se-Alzheimer evimbela i-AChE eguquguqukayo ewela umgoqo wegazi nobuchopho. Inciphisa ukufa kwamaseli okubangelwa yi-glutamate emasikweni ayisisekelo avela ku-forebrain, hippocampus, cortex kanye ne-cere.