I-Hydrocortisone, i-11β, 17,21-trihydroxypregn-4-ene-3,20-dione, iyinhloko ye-GCin yemvelo yabantu.Naphezu kwenani elikhulu lama-GC okwenziwa, i-hydrocortisone, ama-ester ayo, nosawoti bayo kusalokhu kuyinsika yokwelashwa kwesimanjemanje kwe-adrenocortical steroid kanye nezinga lokuqhathaniswa kwawo wonke amanye ama-GC nama-MC.Isetshenziselwa zonke izinkomba okukhulunywe ngazo ngaphambili.