I-Natamycin/Pimaricin CAS: 7681-93-8 Umhlinzeki Womkhiqizi

I-Pimaricin iyi-tetraene yama-macrocyclic eyahlukaniswa okokuqala ne-Streptomyces natalensis ngo-1957. I-Pimaricin ibonisa umsebenzi we-antifungal obanzi ngokumelene nemvubelo kanye ne-filamentous fungi ngokubopha ngqo ku-ergosterol ukuvimba ukukhula kwe-fungus. Ngokungafani nama-polyene ahlobene, i-nystatin kanye ne-filipin, i-pimaricin ayishintshi ukungena kwe-plasma membrane. I-Pimaricin isetshenziswa embonini yokudla ekwelapheni ushizi njengomvimbeli wesikhunta. I-Natamycin iyi-antibiotic ye-polyene eyenziwe ngendlela ethile. I-Natamycin ayincibiliki emanzini futhi ngeke ingene kwi-epithelium ye-cornea engaguquki. I-Natamycin yiyona kuphela i-antifungal agent evunyelwe ukusetshenziswa esweni futhi iyona kuphela umuthi wamehlo otholakala kwezentengiselwano ekwelapheni i-fungus keratitis. I-Natamycin, eyaziwa nangokuthi i-pimaracin, ingeyomndeni wama-antibiotic e-polyene; (iqembu lama-antifungal agents ahlose futhi abopha kuma-sterols eukaryotic kanye ne-ergosterol ikakhulukazi), futhi iyi-metabolite yesibili ye-Streptomyces natalensis.