I-Bethahistinemethanesulfonate CAS:54856-23-4

I-Bethahistinemethanesulfonate isetshenziswa kakhulu emkhakheni wezokwelapha, ikakhulukazi ngezinzuzo zayo zokwelapha ekwelapheni izifo ze-vestibular ezifana nesifo sikaMeniere nezinye izimo ezihlobene nokulinganisela. Isifo sikaMeniere sihilela iziqephu ze-vertigo, i-tinnitus, kanye nokulahlekelwa ukuzwa, okubangelwa ukungajwayelekile koketshezi endlebeni yangaphakathi. Ukunikezwa kwe-Bethahistinemethanesulfonate kungasiza ekunciphiseni lezi zimpawu ngokuthuthukisa ukugeleza kwegazi endlebeni yangaphakathi, ngaleyo ndlela kuzinziswe uhlelo lwe-vestibular futhi kuncishiswe ukuvama nobukhali beziqephu ze-vertiginous. Ngaphezu kwezifo ze-vestibular, i-Bethahistinemethanesulfonate ingaba wusizo ekwelapheni ezinye izimo ezihambisana nokuphazamiseka kokujikeleza kwegazi. Ngokusebenza njenge-vasodilator, kusiza ukuthuthukisa ukugeleza kwegazi ezicutshini ezahlukahlukene, okwenza kube wusizo ezigulini ezinezifo zemithambo yegazi. Lokhu kuthuthukiswa kokujikeleza kwegazi kungathuthukisa ukulethwa komoya-mpilo nezakhamzimba ezindaweni ezithintekile, kukhuthaze ukuphulukiswa nokusebenza okungcono. Ngaphezu kwalokho, ucwaningo lukhombisile ukusetshenziswa okungenzeka kwe-Bethahistinemethanesulfonate ekuvikeleni izinzwa nasekuthuthukiseni ingqondo. Isenzo sayo njenge-agonist ye-histamine receptor sibonisa ukuthi ingadlala indima ekulawuleni ukukhululwa kwe-neurotransmitter, ngaleyo ndlela ithonye izinqubo zokuqonda futhi inikeze imiphumela yokuvikela imizwa ezifweni eziwohlokayo zemizwa. Le nhlanganisela ingacatshangelwa futhi ukuthi isetshenziswe kwezinye izimo, njengokwelashwa kwemiphumela ethile yokungezwani komzimba ngenxa yomsebenzi wayo we-histamine. Kodwa-ke, ukusetshenziswa kwayo kule ndawo kudinga ucwaningo olwengeziwe kanye nokuqinisekiswa. Sekukonke, i-Bethahistinemethanesulfonate iyi-ejenti yokwelapha ehlukahlukene eqashelwa ngemiphumela yayo emihle ekusebenzeni kwe-vestibular kanye nokujikeleza kwegazi, ikhombisa ithemba ezinhlelweni ezahlukene zezokwelapha ezigxile ekuthuthukiseni ikhwalithi yokuphila kwesiguli.