I-N-methyl-2,2,2-trifluoroacetamide CAS:815-06-5

I-N-Ethyl 2-methyl-4,4,4-trifluoroacetoacetate (EMTFA) ibonakaliswa yisakhiwo sayo sama-molecule, esihlanganisa iqembu le-trifluoromethyl (-CF3) elixhunywe kumgogodla we-β-keto ester. Lesi sakhiwo sinikeza ukuzinza okukhulu kanye nokusabela ku-EMTFA, okwenza ifaneleke ukusetshenziswa kwamakhemikhali ahlukahlukene. I-EMTFA ivame ukuba khona njengoketshezi olucacile, olungenambala olunendawo yokubila ezungeze i-140°C futhi ikhombisa ukuncibilika okuhle ezinyibilikisini ezivamile ze-organic ezifana ne-acetone ne-ethyl acetate. Ukuqina kwayo ngaphansi kwezimo ezahlukahlukene kuvumela ukusetshenziswa kwayo ngempumelelo kokubili ocwaningweni lwelabhorethri kanye nezinqubo zezimboni. Ukusetshenziswa Kwe-Organic Synthesis: I-EMTFA isebenza njengebhloko ebalulekile yokwakha ekwenziweni kwezinto eziphilayo, ikakhulukazi ekwethulweni kwe-motifs ye-trifluoromethylated kuma-molecule e-organic. Leli khono libalulekile ekuthuthukiseni imithi, amakhemikhali ezolimo, kanye namakhemikhali akhethekile anomsebenzi othuthukisiwe we-biological kanye nokuqina kwamakhemikhali. I-Pharmaceutical Chemistry: Ekusetshenzisweni kwemithi, i-EMTFA isetshenziswa njengesandulela ekwenziweni kwezithako zemithi ezisebenzayo (ama-API) ngenxa yamandla ayo okunikeza izakhiwo zemithi ezifiselekayo. Idlala indima ebalulekile kumakhemikhali ezokwelapha ngokuvumela ukuguqulwa kwama-molecule emithi ukuthuthukisa ukusebenza kahle nokunciphisa ukuthambekela kwe-metabolic. Amakhemikhali Akhethekile: I-EMTFA ithola ukusetshenziswa ekukhiqizweni kwamakhemikhali akhethekile njengemithi yokubulala ukhula, izibulala-zinambuzane, kanye nezinto eziyinkimbinkimbi ezisetshenziswa ekuhlanganiseni amakhemikhali ezolimo namakhemikhali amahle. Ukuguquguquka kwayo ekuguqulweni kwamakhemikhali kuyenza ibe yigugu ekwakhiweni lapho kudingeka khona ukulawula okunembile isakhiwo kanye nokusebenza kwama-molecule. Ukwenziwa kwe-Ethyl 2-methyl-4,4,4-trifluoroacetoacetate kwenziwa ngenqubo yezinyathelo eziningi eqala ngokusabela kwe-Claisen condensation kwe-ethyl trifluoroacetate nge-methyl acetate, kulandelwe yi-esterification ngaphansi kwezimo ezilawulwayo. Ukusabela kuvame ukuqhubeka lapho kukhona i-catalyst eyisisekelo ukuze kube lula ukwakheka kwe-β-keto ester. Amasu okuhlanza njenge-distillation noma i-recrystallization asetshenziswa ukuthola i-EMTFA ngobumsulwa obukhulu efanelekile ukusetshenziswa kwezimboni. Indlela eqondile yokwenziwa kanye nokutholakala kwezinto zokuqala kunegalelo ekusebenzeni kwayo kahle kwezindleko kanye nokusetshenziswa kabanzi ocwaningweni lwezemfundo kanye nezinqubo zezimboni. Ngamafuphi, i-ethyl 2-methyl-4,4,4-trifluoroacetoacetate iyinhlanganisela eguquguqukayo enezicelo ezibalulekile ekuhlanganisweni kwezinto eziphilayo, ikhemistri yemithi, kanye nokukhiqizwa kwamakhemikhali akhethekile. Izakhiwo zayo zamakhemikhali ezihlukile, okuhlanganisa ukuzinza, ukusabela, kanye nokulula kokuhlanganiswa, ziyibeka njengomdlali obalulekile ekuthuthukisweni kobuchwepheshe emikhakheni eyahlukene yezimboni kanye nemikhakha yesayensi.