I-N-methyl-2,2,2-trifluoroacetamide CAS:815-06-5

I-N-Methyl-2,2,2-trifluoroacetamide (NMTFA) ibonakaliswa ngesakhiwo sayo sama-molecule, esihlanganisa iqembu le-trifluoromethyl (-CF3) elixhunywe kumgogodla we-acetamide (-CONHCH3). Lesi sakhiwo sinikeza ukuzinza okukhulu kanye nokusabela ku-NMTFA, okwenza ifaneleke ezinhlobonhlobo zezicelo zamakhemikhali. I-NMTFA ivame ukuba khona njenge-crystalline solid enephuzu lokuncibilika elingaba ngu-62°C futhi ibonisa ukuncibilika okuhle ezinyibilikisweni ze-polar organic ezifana ne-acetone ne-ethanol. Ukuqina kwayo ngaphansi kwezimo ezahlukahlukene kuvumela ukusetshenziswa kwayo ngempumelelo kokubili ocwaningweni lwelabhorethri kanye nezinqubo zezimboni. Ukusetshenziswa Kwe-Organic Synthesis: I-NMTFA isebenza njengomxhumanisi obalulekile ekuhlanganisweni kwezinto eziphilayo, ikakhulukazi ekwethulweni kwamaqembu e-trifluoromethyl kuma-molecule ezinto eziphilayo. Leli khono libalulekile ekuthuthukiseni imithi, amakhemikhali ezolimo, kanye namakhemikhali akhethekile anomsebenzi othuthukisiwe wezinto eziphilayo kanye nokuqina kwamakhemikhali. I-Pharmaceutical Chemistry: Ekusetshenzisweni kwemithi, i-NMTFA isetshenziswa njengesandulela ekuhlanganisweni kwezithako zemithi ezisebenzayo (ama-API) ngenxa yamandla ayo okunikeza izakhiwo zemithi ezifiselekayo. Idlala indima ebalulekile kumakhemikhali ezokwelapha ngokuvumela ukuguqulwa kwama-molecule emithi ukuze kuthuthukiswe ukusebenza kahle futhi kuncishiswe ukuthambekela kwe-metabolic. Amakhemikhali Akhethekile: I-NMTFA ithola ukusetshenziswa ekukhiqizweni kwamakhemikhali akhethekile afana nama-surfactants, ama-plasticizer, kanye nama-intermediate ayinkimbinkimbi asetshenziswa ekwakhiweni kwamakhemikhali ezolimo namakhemikhali amahle. Ukuguquguquka kwayo ekuguqulweni kwamakhemikhali kuyenza ibe yigugu ekwakhiweni lapho kudingeka khona ukulawula okunembile isakhiwo sama-molecule kanye nokusebenza kwawo. Ukwenziwa kwe-N-Methyl-2,2,2-trifluoroacetamide kwenziwa ngokusabela kwe-trifluoroacetic acid ne-methylamine. Le nqubo ihilela ukujiya kwe-trifluoroacetic acid ne-methylamine ngaphansi kwezimo ezilawulwayo ukuze kwakheke i-NMTFA. Ukusabela kuvame ukuqhubeka lapho kukhona i-catalyst efanelekile ukuze kube lula ukwakheka kwe-amide bond. Amasu okuhlanza anjenge-recrystallization noma i-chromatography asetshenziswa ukuze kutholakale i-NMTFA ngobumsulwa obukhulu efanelekile ukusetshenziswa kwezimboni. Indlela eqondile yokwenziwa kanye nokutholakala kwezinto zokusetshenziswa kunegalelo ekusebenzeni kwayo kahle kwezindleko kanye nokusetshenziswa kabanzi ocwaningweni lwezemfundo kanye nezinqubo zezimboni. Ngamafuphi, i-N-methyl-2,2,2-trifluoroacetamide iyinhlanganisela eguquguqukayo enezicelo ezibalulekile ekuhlanganisweni kwezinto eziphilayo, ikhemistri yemithi, kanye nokukhiqizwa kwamakhemikhali akhethekile. Izakhiwo zayo zamakhemikhali ezihlukile, okuhlanganisa ukuzinza, ukusabela, kanye nokulula kokuhlanganiswa, kunegalelo ekubalulekeni kwayo ekuthuthukiseni ubuchwepheshe emikhakheni eyahlukene yezimboni kanye nemikhakha yesayensi.