I-Mirabegron CAS:223673-61-8 Isithombe Esifakiwe Somhlinzeki Womkhiqizi

Mirabegron CAS:223673-61-8 Umkhiqizi Supplier

I-Mirabegron ingeyokwelashwa kokuphuthuma, imvamisa yokuchama, kanye ne-urinary urge incontinence yomchamo ehambisana nesinye esisebenza ngokweqile (OAB).I-Mirabegron ihlanganiswa ngokuhlanganisa i-4-nitrophenethyl amine ku-(R) -2-hydroxy-2-phenylacetic acid.I-amide ewumphumela iyancipha ibe i-amine.Iqembu le-nitro libe selincishiswa bese umphumela uhlanganiswa ne-2-(2-aminothiazol-4-yl) i-acetic acid ukunikeza i-mirabegron.

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I-Mirabegron iyi-agonist esebenza ngomlomo i-β3-adrenoceptor okwamanje esakhiwa i-Astellas Pharma yokwelapha esinyeni esisebenza ngokweqile (OAB).Umuthi uyimbangi ye-nanomolar EC50 emelene nokuhlolwa kwe-biochemical ye-β3-AR yabantu ngokukhetha okuhle ngaphezu kwe-b1- kanye ne-β2-AR.I-Mirabegron ibonisa indlela yenoveli ngokukhomba i-β3-AR yokuphumuza isinye ukuze isize ukuphatha izimpawu ze-OAB ezifana nokukhuphuka kokuphuthuma komchamo kanye nemvamisa kanye nokungakwazi ukuzithiba okuphuthumayo.Kodwa-ke, i-mirabegron iyi-cytochrome P450 2D6 inhibitor, futhi iphakamisa ukukhathazeka ngokusebenzisana kwezidakamizwa nokuphathwa okuhambisanayo kwamanye ama-substrates e-cytochrome P450 2D6.

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Ukupakishwa komkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	I-C21H24N4O2S
Isivivinyo	99%
Ukubukeka	Impushana emhlophe kuya kokuphuzi
Inombolo ye-CAS.	223673-61-8
Ukupakisha	25KG
I-Shelf Life	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	ISO.