Umhlinzeki Womkhiqizi we-Empagliflozin CAS:864070-44-0

I-Empagliflozin iyisivimbeli esisha, esinamandla nesikhethayo se-SGLT-2, ithuthukisa ukulawulwa kwe-glycemic kanye nezici ze-metabolic syndrome kumagundane anesifo sikashukela. I-Empagliflozin (igama lokuhweba elithi Jardiance) iyisivimbeli se-sodium glucose co-transporter-2 (SGLT-2), futhi ibangela ukuthi ushukela egazini ukhishwe yizinso futhi ukhishwe emchameni. I-Empagliflozin ingabangela ukuphelelwa amanzi emzimbeni futhi iholele ekwehleni komfutho wegazi, okuholela ezigulini ezinesiyezi noma ukuquleka kanye nokusebenza kwezinso okwehlayo. Ingozi yeziguli ezindala, ikakhulukazi lezo ezingasebenzi kahle kwezinso kanye nezidakamizwa zokukhipha isisu, ibonakala inkulu. I-FDA idinga uBoehring no-Eli Lilly ukuthi benze izifundo ezine zangemva kokumaketha: ukuhlolwa okuphelele kwemiphumela yenhliziyo nemithambo yegazi okuqhubekayo, ukuhlolwa kwe-pharmacokinetics yezingane kanye ne-pharmacodynamics, ukuhlolwa kokuphepha kwezingane kanye nokusebenza kahle, ukuhlolwa kobuthi bomuthi (ikakhulukazi umphumela wokusebenza kwezinso, amathambo nokukhula kanye nentuthuko).