I-Mirabegron CAS:223673-61-8 Umhlinzeki Womkhiqizi

I-Mirabegron yenzelwe ukwelapha ukuphuthuma, imvamisa yomchamo, kanye nokungalawuleki komchamo okuhambisana nesinye esisebenza ngokweqile (OAB). I-Mirabegron yenziwa ngokuhlanganisa i-4-nitrophenethyl amine ne-(R)-2-hydroxy-2-phenylacetic acid. I-amide ephumayo incishiswa ibe yi-amine. Iqembu le-nitro liyancishiswa bese umphumela uhlanganiswa ne-2-(2-aminothiazol-4-yl) acetic acid ukuze kunikezwe i-mirabegron.

Oda noma Cela Isilinganiso

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Ukusetshenziswa kanye Nomphumela

I-Mirabegron iyi-agonist esebenza ngomlomo ye-β3-adrenoceptor okwamanje esakhiwa yi-Astellas Pharma yokwelapha isinyi esisebenza ngokweqile (i-OAB). Lesi sidakamizwa siyisitha se-nanomolar EC50 ngokumelene nokuhlolwa kwe-β3-AR yabantu ngokukhetha okuhle ngaphezu kwe-b1- kanye ne-β2-AR. I-Mirabegron ikhombisa indlela entsha ngokugxila ku-β3-AR yokuphumula isinyi ukusiza ukuphatha izimpawu ze-OAB ezifana nokwanda kokuphuthuma komchamo kanye nokuvama kanye nokungalawuleki ngokushesha. Kodwa-ke, i-mirabegron iyisivimbeli se-cytochrome P450 2D6, futhi iphakamisa ukukhathazeka ngokusebenzisana kwezidakamizwa kanye nokuphathwa kanyekanye kwezinye izingxenye ze-cytochrome P450 2D6.

Isampula Yomkhiqizo

Ukupakisha Umkhiqizo:

Ulwazi Olwengeziwe:

Ukwakheka	C21H24N4O2S
Ukuhlolwa	99%
Ukubukeka	Impuphu emhlophe kuya kwephuzi elikhanyayo
Inombolo ye-CAS	223673-61-8
Ukupakisha	25KG
Impilo Yeshelufu	iminyaka engu-2
Isitoreji	Gcina endaweni epholile neyomile
Isitifiketi	I-ISO.