I-Linezolid CAS:165800-03-3

I-Linezolid isetshenziswa kabanzi emitholampilo yokwelapha ukuphatha izifo ezibangelwa amagciwane aqinile e-Gram-positive amelana namanye ama-antibiotic. Ngokuvamile inqunyelwe izifo zesikhumba nezicubu ezithambile, i-pneumonia, i-bacteremia, kanye nezifo zamathambo ezibangelwa yi-MRSA, i-VRE, kanye nezinye izifo ezimelana nemithi eminingi. Amandla e-Linezolid okuhlasela lezi zinto eziphilayo okunzima ukuzelapha ayenza ibe yinto ebalulekile yokwelapha ekulweni nezifo eziyinselele. Ezindaweni zasesibhedlela, i-linezolid ivame ukusetshenziswa ekwelapheni izifo ze-nosocomial kanye ne-pneumonia ehlobene nokunakekelwa kwempilo ngenxa yomsebenzi wayo obanzi kanye nephrofayili yokuphepha enhle. Ukwakheka kwayo ngomlomo kuvumela ukwelashwa okulula kwezifo ezithile ngaphandle kwesibhedlela, okunikeza iziguli ukwelashwa okuphumelelayo ngokumelene namagciwane abangela izinkinga. Ngaphezu kwalokho, i-linezolid isetshenziswa ekwelapheni isifo sofuba kanye nezinye izifo ze-mycobacterial njengengxenye yezindlela zokwelapha ezihlanganisiwe. Indlela yayo ehlukile yokusebenza kanye nokungena okuhle kwezicubu kwenza kube yinto ewusizo ekwelapheni isifo sofuba esingamelana nemithi kanye nezifo ze-mycobacterial ezingezona i-tuberculous. Ezindaweni zocwaningo, i-linezolid isetshenziswa njengendinganiso yokubhekisela ekuhlolweni kokuzwela kwamagciwane ukuhlola ukuzwela kwama-bacterial isolates kule antibiotic. Ngokunquma ukuhlushwa okuncane kokuvimbela (i-MIC) kwe-linezolid ngokumelene namagciwane athile, abacwaningi bangaqondisa amasu okwelapha afanele futhi baqaphe amaphethini okumelana. Sekukonke, i-linezolid idlala indima ebalulekile ekuphathweni kokutheleleka kwamagciwane okune-Gram-positive okuyinselele, inikeza odokotela inketho yokwelapha enamandla nethembekile ngokumelene namagciwane amelana nemithi. Ukusebenza kwayo kahle, ukubekezeleleka, kanye nokuguquguquka kwayo kwenza kube yingxenye ebalulekile ekulweni nezifo ezithathelwanayo, ikakhulukazi lezo ezibangelwa amagciwane amelana nemithi eminingi.