I-Ethionamide CAS:536-33-4

I-Ethionamide iyisici esibalulekile ekuphathweni kwesifo sofuba esingamelana nemithi eminingi (i-MDR-TB) kanye nesifo sofuba esingamelana nemithi eminingi (i-XDR-TB), izinhlobo ezimbili ze-TB ezingamelana nemithi ejwayelekile yokuqala. Le mithi elwa namagciwane ivame ukusetshenziswa njengengxenye yohlelo lokwelapha oluphelele oluqukethe imithi eminingi yokulwa nokutheleleka kwe-TB okubangelwa izinhlobo ezingamelana nemithi. I-Ethionamide isebenza ngokuphazamisa ukwakheka kwama-mycolic acid ngaphakathi kodonga lweseli lebhaktheriya lesifo sofuba i-Mycobacterium, ngaleyo ndlela ivimbele ukukhula nokuphindaphindeka kwamagciwane. Kubalulekile ukulandela umthamo onqunyiwe nokuqedela inkambo ephelele yokwelashwa ukuze kufezwe imiphumela emihle yokwelapha futhi kuvinjelwe ukuthuthukiswa kokumelana nemithi okuqhubekayo. Imiphumela emibi evamile ye-ethionamide ingafaka izinkinga zesisu njengokucanuzela, ukuhlanza, nobuhlungu besisu, kanye nezimpawu zemizwa njenge-peripheral neuropathy. Ukuqapha njalo ngabahlinzeki bezempilo kuyadingeka ukuze kuhlolwe ukusebenza kahle kokwelashwa futhi kuphathwe noma yikuphi ukusabela okubi ngokushesha. Iziguli kufanele zilandele ngokuqinile uhlelo lwazo lokwelashwa kanye nokuqokwa kokulandelela ukuze kuqashwe inqubekela phambili futhi kuqinisekiswe ukululama ngempumelelo ekuthelelekeni kwe-TB. I-Ethionamide idlala indima ebalulekile ekulweni nesifo sofuba esingamelana nemithi futhi igcizelela ukubaluleka kwendlela yokusebenzisa imithi eminingi ekubhekaneni nomthwalo womhlaba wonke walesi sifo esithathelwanayo.