I-Fmoc-D-Asn(Trt)-OH CAS:180570-71-2

I-Fmoc-D-Asn(Trt)-OH ibalulekile ekwakhiweni kwama-peptide, ikakhulukazi ekwakheni ama-peptide aqukethe i-D-enantiomer ye-asparagine ngokunemba. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwama-peptide, kuyilapho iqembu le-trityl lengeza ungqimba olwengeziwe lokuvikela. Abacwaningi basebenzisa i-Fmoc-D-Asn(Trt)-OH kakhulu ekwakhiweni kwama-peptide ezinhlelo zokusebenza ezahlukahlukene, okuhlanganisa ukuthuthukiswa kwemithi, izinto eziphilayo, kanye nokuklama ama-peptide asebenzayo anezilungiselelo ezithile ze-stereochemical. Ukuhambisana kwayo nezindlela ezijwayelekile zokwenziwa kwama-peptide, kokubili kumasu esigaba esiqinile kanye nesigaba sesisombululo, kuthuthukisa ukuguquguquka kwayo emizamweni yocwaningo eyahlukahlukene. Ukususwa okulawulwayo kwamaqembu avikelayo kuvumela ukufakwa kwe-D-asparagine ngamasu okulandelana kwama-peptide, kwandise i-repertoire yama-peptide angenziwa. Ngaphezu kwalokho, i-Fmoc-D-Asn(Trt)-OH ithola usizo ekwakhiweni kwama-peptide ocwaningo lwe-proteomics kanye nokufunda izinqubo zamaseli. Ukusetshenziswa okunesu kweqembu lokuvikela i-trityl kwenza kube lula ukusebenzisa i-D-asparagine reactivity ngendlela enembile, okunikeza abacwaningi ithuluzi eliwusizo lokuklama ama-peptide anezinguquko ezenziwe ngokwezifiso. Ngamafuphi, i-Fmoc-D-Asn(Trt)-OH imele njengethuluzi eliguquguqukayo nelibalulekile kumakhemikhali e-peptide, okunika abacwaningi amandla okuhlola nokuguqula i-D-asparagine reactivity yezinhlelo zokusebenza zesayensi ezahlukahlukene, ikakhulukazi ukugxila kuma-peptide aqukethe ama-D-amino acid.