I-Fmoc-Arg(Tos)-OH CAS:83792-47-6

I-Fmoc-Arg(Tos)-OH idlala indima ebalulekile ekwakhiweni kwe-peptide, ikakhulukazi lapho kudingeka ukuvikelwa okunembile kwe-guanidine nitrogen ku-arginine. Iqembu elivikela i-Fmoc livikela iqembu lama-amino, liqinisekisa ukusabela okukhethayo ngesikhathi sokuhlanganiswa kwe-peptide, kuyilapho iqembu le-tosyl ku-guanidine nitrogen linikeza ungqimba olwengeziwe lokuvikela. Abacwaningi basebenzisa i-Fmoc-Arg(Tos)-OH ekwakhiweni kwama-peptide ngokuguqulwa okuthile kwe-guanidine, okuthonya imisebenzi yabo yezinto eziphilayo. Indlela yokuvikela ephindwe kabili ivumela ukuphathwa okulawulwayo kwe-reactivity ye-guanidine, okwenza le nhlanganisela ibe usizo ekwakhiweni kwama-peptide ezifundweni zokulwa namagciwane, i-bioconjugation, kanye ne-chemistry yezokwelapha. Ukuhambisana kwe-Fmoc-Arg(Tos)-OH nezindlela ezijwayelekile zokwenziwa kwe-peptide, kufaka phakathi ukwakheka kwe-peptide yesigaba esiqinile (i-SPPS), kuthuthukisa ukusebenza kwayo. Le nhlanganisela ithola ukusetshenziswa ekwakheni ama-peptide okuhlolwa kwezinto eziphilayo, ukutholakala kwemithi, kanye nokuthuthukiswa kwezinto ezisekelwe kuma-peptide. Ukususwa okulawulwayo kwamaqembu avikelayo kuvumela ukufakwa kwe-arginine ne-guanidine eguquliwe, okufaka isandla ekwahlukeni kwama-peptide angakhiwa. Ngamafuphi, i-Fmoc-Arg(Tos)-OH imele njengethuluzi elikhethekile neliguquguqukayo kumakhemikhali e-peptide, okunika amandla abacwaningi ukuthi bahlole futhi bashintshe ukusabela kwe-guanidine kwezinhlelo zokusebenza zesayensi nezokwelapha ezahlukahlukene.