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i-guanosine 5′- (disodium dihydrogen triphosphate) i-CAS:56001-37-7
I-Guanosine-5′-triphosphate disodium iyinhlanganisela esetshenziswa ezinqubweni ezahlukene ze-biochemical, njengokwenziwa kwe-RNA ne-DNA, kanye nasezindleleni zokudlulisela isignali. Iyi-nucleoside triphosphate, okusho ukuthi iqukethe i-nucleoside guanosine exhunywe emaqenjini amathathu e-phosphate. Uhlobo lwe-disodium salt lubonisa nje ukuthi usawoti oqukethe ama-ion amabili e-sodium.
Le nhlanganisela ibalulekile ekudlulisweni kwamandla eseli futhi ihilelekile ekuphenduleni okuhlukahlukene kwama-enzyme. Futhi ingumthombo wamandla wokwenziwa kwamaprotheni nezinye izinqubo zamaseli.
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I-2′-Deoxyuridine CAS:951-78-0 Intengo Yomkhiqizi
I-2′-Deoxyuridine iyi-nucleoside equkethe i-nucleobase uracil exhunywe kushukela we-deoxyribose. Iyisakhiwo esibalulekile se-DNA futhi ihilelekile ekuphindaphindweni nasekubhalweni kwezinto zofuzo. I-2′-Deoxyuridine isetshenziswa ocwaningweni lwesayensi njengesandulela sokwenziwa kwe-DNA kanye nakwezindlela ezahlukahlukene zebhayoloji yama-molecular. Idlala indima ebalulekile ekuqondeni izinqubo zofuzo, kanye nasekuthuthukisweni kwezicelo zokwelapha ezingaba khona ezindaweni ezifana nokwelashwa ngamagciwane kanye nokwelashwa komdlavuza.
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I-Adenosine5′-(trihydrogen diphosphate), usawoti we-monopotassium, i-dihydrate (9CI) I-CAS:72696-48-1
i-adenosine 5′- (i-trihydrogen diphosphate) usawoti we-monopotassium, i-dihydrate, iyinhlanganisela yamakhemikhali equkethe i-adenosine eneqembu le-trihydrogen diphosphate kanye nosawoti we-monopotassium ngesimo se-dihydrate. Le nhlanganisela ivame ukubizwa ngokuthi i-adenosine diphosphate (ADP), edlala indima ebalulekile ezinqubweni ezahlukene zezinto eziphilayo, ikakhulukazi ekudlulisweni kwamandla ngaphakathi kwamaseli.
I-ADP iyisici esibalulekile emalini yamandla yeseli, njengoba ihilelekile ekudlulisweni kwamandla ngesikhathi sokuphefumula kwamaseli kanye ne-photosynthesis. Futhi iyisandulela se-adenosine triphosphate (ATP), eyisithwali esiyinhloko samandla kumaseli.
Ngaphezu kwalokho, i-ADP ihilelekile ezindleleni zokudlulisa isignali futhi iyisizinda sokusabela kwe-enzyme. Ngokwesimo se-biochemistry kanye ne-molecular biology, i-ADP isetshenziswa kabanzi ezifundweni ezihlobene nokusetshenziswa kwe-metabolism yamaseli, i-enzyme kinetics, kanye nezinqubo zokudlulisa amandla.
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I-Hypoxanthine CAS: 68-94-0 Intengo Yomkhiqizi
I-Hypoxanthine iyinhlanganisela eyenzeka ngokwemvelo eyingxenye ebalulekile ekuwohlokeni kwama-purines. Iyingxenye ebalulekile yama-nucleic acid futhi ihilelekile ezinqubweni ezahlukene zebhayoloji, okuhlanganisa ukwakheka kanye nokusetshenziswa kwe-metabolism ye-DNA ne-RNA. Ngaphezu kwalokho, i-hypoxanthine itholakale idlala indima ezimweni ezithile zempilo, njenge-gout kanye ne-Lesch-Nyhan syndrome.
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I-2′-O-Methyluridine CAS:2140-76-3 Intengo Yomkhiqizi
I-2′-O-Methyluridine iyi-nucleoside eguquliwe equkethe iqembu le-methyl endaweni engu-2′ yendandatho ye-ribose. Iyisakhiwo esibalulekile ekuhlanganisweni kwama-molecule e-RNA aguquliwe futhi ifundwe ngezakhiwo zayo ezingaba khona zezinto eziphilayo nezemithi. Ezinye zezicelo zayo ezibikiwe zifaka phakathi ukusetshenziswa kwayo ocwaningweni lwe-RNA, njengengxenye ekukhiqizweni kwe-RNA eguquliwe yezicelo zokwelapha nezokusebenza kwe-genomics, kanye nethuluzi ocwaningweni lwesakhiwo nomsebenzi we-RNA.
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I-4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one I-CAS:951-77-9
I-2′-Deoxycytidine iyi-nucleoside eyakhiwe yi-nucleobase cytosine exhunywe ku-sugar deoxyribose. Iyingxenye ebalulekile ye-DNA futhi idlala indima ebalulekile ekugcinweni nasekudluliselweni kolwazi lwezakhi zofuzo ngaphakathi kwezinto eziphilayo.
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I-Cytidine-5′-monophosphate (CMP), i-asidi yamahhala i-CAS:63-37-6
I-Cytidine 5'-monophosphate (CMP) iyi-nucleotide esebenza njengesisekelo sokwakhiwa nokuguqulwa kwe-RNA. Iyingxenye ebalulekile ekwakhiweni kwama-molecule e-RNA futhi ihilelekile ezinqubweni ezifana nokugoba kwe-mRNA kanye ne-metabolism ye-nucleotide. I-CMP isetshenziswa futhi ocwaningweni lwe-biochemical kanye ne-molecular biology lwezinhlelo zokusebenza ezifana nokubhalwa kwe-in vitro kanye nokulebula i-nucleic acid. Indima yayo ku-metabolism ye-RNA kanye nokusetshenziswa kwayo kumasu ahlukahlukene okuhlola kwenza kube ithuluzi elibalulekile ekuqondeni isakhiwo kanye nomsebenzi wama-molecule e-RNA.
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I-IBMX, i-3-isobutyl-1-methylxanthine CAS:28822-58-4
I-3-isobutyl-1-methylxanthine, eyaziwa nangokuthi i-IBMX, iyi-derivative ye-methylxanthine evame ukusetshenziswa ocwaningweni lwesayensi njengesivimbeli esingaqondile sama-cyclic nucleotide phosphodiesterases. Kwaziwa ukuthi ikhulisa amazinga angaphakathi kweseli e-cyclic AMP (cAMP) kanye ne-cyclic GMP (cGMP) ngokuvimbela ukuwohloka kwawo, okungaguqula izindlela ezahlukene zokuthumela izimpawu zamaseli.
Ngaphezu kwezicelo zayo zocwaningo, i-IBMX isetshenziswe kwezinye izindawo zezokwelapha ngenxa yemiphumela yayo ye-bronchodilator kanye ne-vasodilator. Kodwa-ke, ukusetshenziswa kwayo kwezokwelapha kwabantu kulinganiselwe.
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4-Nitrophenyl phosphate disodium salt hexahydrate CAS:4264-83-9
I-4-Nitrophenyl phosphate disodium salt hexahydrate iyinhlanganisela yamakhemikhali evame ukusetshenziswa ocwaningweni lwe-biochemical kanye nemithi. Iwuhlobo lukasawoti lwe-4-nitrophenyl phosphate, equkethe ama-ion amabili e-sodium nama-molecule amanzi ayisithupha. Le nhlanganisela ivame ukusetshenziswa njengesisekelo sokuhlolwa kwe-phosphatase kanye nasekufundweni kwe-enzyme kinetics.
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I-5′-Deoxy-5-fluorocytidine CAS:66335-38-4
I-5′-Deoxy-5-fluorocytidine iyi-analog ye-nucleoside yokwenziwa ephenywayo ngomsebenzi wayo ongaba khona wokulwa namagciwane, ikakhulukazi ngokumelene namagciwane e-RNA njengegciwane le-hepatitis C (HCV) kanye namagciwane e-flavi. Isebenza ngokuphazamisa ukuphindaphindeka kwezinto zofuzo zegciwane, ekugcineni ivimbele ikhono legciwane lokwanda nokusabalala emzimbeni.
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I-Cytidine-5′-triphosphate (CTP), usawoti we-disodium I-CAS:652154-13-7
I-Cytidine-5′-triphosphate (CTP), usawoti we-disodium iyi-triphosphate ye-nucleoside esebenza njengesisekelo sokwakhiwa kwe-RNA. Idlala indima ebalulekile ekusetshenzisweni kwe-metabolism yamaseli futhi ibalulekile ekudlulisweni kolwazi lwezakhi zofuzo kusuka ku-DNA kuya ku-RNA ngesikhathi sokubhalwa. I-CTP isetshenziswa kabanzi ocwaningweni lwe-molecular biology, ikakhulukazi ezifundweni ezihlobene nokwakheka kwe-RNA, ukuphazamiseka kwe-RNA, kanye nezinye izinqubo ezihlobene ne-RNA. Ngaphezu kwalokho, isetshenziswa ekuphenduleni kwe-enzyme, ezifundweni ze-nucleotide metabolism, kanye nanjengesisekelo sokuhlolwa okuhlukahlukene kwe-biochemical. Embonini yezemithi, i-CTP ingaba nezicelo ezingaba khona ekuthuthukisweni kwemithi yokulwa namagciwane kanye neyomdlavuza.
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ITP, inosine 5′-triphosphate trisodium salt CAS:35908-31-7
Usawoti we-Inosine-5′-triphosphate trisodium, ovame ukufushaniswa ngokuthi i-ITP-Na3, uwuhlobo lwe-inosine lwe-triphosphate, i-nucleoside edlala indima ebalulekile ezinqubweni ezahlukene zezinto eziphilayo. Le nhlanganisela iyisimo sikasawoti, okwenza incibilike emanzini futhi ifanele ukusetshenziswa ekuhlolweni kwamakhemikhali kanye ne-enzymatic, kanye nocwaningo lwe-molecular biology. Usawoti we-Inosine-5′-triphosphate trisodium usetshenziselwa ukufunda ukusabela kwe-enzymatic, i-nucleotide interconversion, kanye ne-substrate yama-enzyme athile. Ukusetshenziswa kwawo kudlulela nasezifundweni ze-nucleotide analog kanye nanjengengxenye ekulungiseleleni izingxube ze-nucleotide ezisetshenziswa kumasu e-molecular biology.
