I-Clascoterone CAS:19608-29-8 Umkhiqizi Womhlinzeki

I-Clascoterone ithuthukiswa njengokhilimu we-topical yi-Cassiopea yezinkinga zesikhumba ezincike ku-androgen.I-Clascoterone (i-cortexolone 17α-propionate, i-CB-03-01) ingumphikisi wenoveli we-androgen receptors.Ibophezela kuma-androgen receptors ngokuhambisana okuphezulu.Ngokuncintisana nama-androgens ngokubophezela kuma-androgen receptors, i-clascoterone isebenza ngokuvimbela i-androgen receptor signaling cascades ekhuthaza i-acne pathogenesis, njengokwanda kwe-sebaceous gland, ukukhiqizwa kwe-sebum ngokweqile, nezindlela zokuvuvukala.Ngo-Agasti 2020, i-FDA yagunyaza i-clascoterone yokwelashwa kwe-acne (acne vulgaris) kwesigaba sokuqala ezigulini zabesilisa nabesifazane ezineminyaka engu-12 nangaphezulu.I-Clascoterone nayo iyaphenywa njengokwelashwa kwe-androgenetic alopecia.