4,4′-Diaminodiphenyl sulfone (Dapsone) CAS:80-08-0

I-Dapsone umuthi ohlukahlukene osetshenziswa ekuphatheni izimo eziningana zesikhumba ngenxa yezakhiwo zayo zokulwa namagciwane kanye nokulwa nokuvuvukala. Ngokuvamile inqunyelwe ukwelashwa kochoko (isifo sikaHansen), isifo esithathelwanayo esingamahlalakhona esibangelwa yi-Mycobacterium leprae esithinta isikhumba kanye nemizwa. I-Dapsone iyasebenza futhi ekwelapheni i-dermatitis herpetiformis, isifo sesikhumba esihlala siqhuma esihambisana nesifo se-celiac. Ngaphezu kwalezi zinkomba eziyinhloko, i-Dapsone ingasetshenziswa ngaphandle kwelebula ukuphatha ezinye izimo zesikhumba ezifana ne-acne vulgaris, i-bullous pemphigoid, kanye ne-cutaneous lupus erythematosus. Umuthi utholakala ngesimo sethebhulethi yomlomo kanye namalungiselelo angaphandle, okuvumela abahlinzeki bezempilo ukuthi bahlele izindlela zokwelapha ngokwezidingo zesiguli ngasinye kanye nobunzima besifo. Iziguli ezithola ukwelashwa kwe-Dapsone kufanele zilandele imiyalelo yomhlinzeki wazo wezempilo ngokucophelela mayelana nokuvama komthamo, isikhathi sokwelashwa, kanye nemiphumela emibi engaba khona. Ukuqapha njalo ukubalwa kwegazi kanye nokuhlolwa kokusebenza kwesibindi kungadingeka ukuqinisekisa ukusetshenziswa kwemithi okuphephile kanye nokutholakala kusenesikhathi kwemiphumela emibi. Kubalulekile ukuthi iziguli zixoxe nganoma yiziphi izinkinga noma izinguquko esimweni sazo nomhlinzeki wazo wezempilo ngesikhathi sokwelashwa nge-Dapsone ukuze kuthuthukiswe imiphumela yokwelapha futhi kuncishiswe ingozi yezinkinga. Ngokunamathela ohlelweni olubekiwe kanye nokugcina ukuxhumana okuvulekile nethimba lazo lezempilo, iziguli zingazuza emiphumeleni yokwelapha ye-Dapsone ekuphatheni izimo ezahlukene zesikhumba ngempumelelo.