1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile CAS:2158267-70-8

I-1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile idlala indima ebalulekile njengomxhumanisi ekwakhiweni kwamakhemikhali ayinkimbinkimbi, asebenzayo kanye nezicelo zemithi ezingaba khona. Ukufakwa kwayo ezinhlakeni zama-molecule kuvumela abacwaningi ukuthi bahlole abantu abasha abazosebenzisa izidakamizwa abahlose izindawo zokwelapha ezahlukahlukene njenge-kinase inhibitors, ama-fluorescent probes, noma izinhlelo ze-chemistry zezinto. Ukuba khona kwe-pyrazole core kanye neqembu le-dioxaborolane kwethula ukusabela okuthile kanye nezakhiwo ze-pharmacophoric, okwenza kube wusizo ocwaningweni lwe-chemistry yezokwelapha. Emizamweni yokuthola izidakamizwa, le nhlanganisela ingasebenza njengendawo yokuqala yokuklama abantu abangaba khona abazosebenzisa izidakamizwa, isebenzisa izici zayo zesakhiwo ukuze iguqule umsebenzi wezinto eziphilayo kanye nezakhiwo ze-pharmacokinetic. Ngaphezu kwalokho, iqembu elisebenzayo le-dioxaborolane linikeza amathuba okuthola okwengeziwe kanye ne-chemistry yokuhlanganisa, okungenzeka kuholele ekuthuthukisweni kwama-molecule amasha anezakhiwo ze-bio ezithuthukisiwe kanye namaphrofayili e-pharmacokinetic athuthukisiwe. Ngaphezu kwalokho, ezindaweni zezemfundo nezezimboni, abacwaningi bangasebenzisa lesi sakhiwo sokwakha ukulungiselela imitapo yolwazi yezinto ezahlukahlukene ezitholakala ezifundweni zobudlelwano besakhiwo nomsebenzi, okwenza kube lula ukuhlonza amakhemikhali e-lead anemiphumela efiselekayo yezinto eziphilayo. Indima yayo ekuhlanganisweni kwamakhemikhali ifinyelela ekukhiqizweni kwezinto ezisetshenziswayo zemithi kanye nokuthuthukiswa kwezindlela ezintsha zokwenziwa, ikhombisa ukusetshenziswa kwayo okubanzi kuzo zonke izigaba zesayensi. Sekukonke, i-1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile idlala indima ebalulekile ekufuneni ukutholakala kwemithi emisha kanye nocwaningo lwamakhemikhali, ihlinzeka ngeplatifomu yokuthuthukiswa kwama-molecule ahlukahlukene asebenzayo ngokwezinto eziphilayo kanye nezinto ezisetshenziswayo ngokwezinto eziphilayo.