I-β-Nicotinamide Adenine Dinucleotide CAS:53-84-9

I-NAD+ ibaluleke kakhulu ekusebenzeni kwamaseli futhi ithole isithakazelo emikhakheni efana nocwaningo lokuguga, i-metabolism, kanye nempilo yamaseli. Njenge-coenzyme, i-NAD+ ibandakanyeka ekuphenduleni kwe-redox okubalulekile ekukhiqizweni kwamandla ngaphakathi kwe-mitochondria, isekela izinqubo ezifana ne-glycolysis, umjikelezo we-tricarboxylic acid, kanye ne-oxidative phosphorylation. Ngaphezu kwalokho, i-NAD+ isebenza njengesisekelo sama-enzyme afana ne-sirtuins nama-PARP, ahilelekile ekulungisweni kwe-DNA, ekulawulweni kokubonakaliswa kwezakhi zofuzo, kanye nezindlela zokuphendula ukucindezeleka kwamaseli. Eminyakeni yamuva nje, izandulela ze-NAD+, njenge-nicotinamide riboside (NR) kanye ne-nicotinamide mononucleotide (NMN), zithole ukunakwa njengezithasiselo ezingaba khona zokusekela amazinga e-NAD+ ngaphakathi kwamaseli. Ucwaningo luphakamisa ukuthi ukugcina amazinga e-NAD+ afanele kungadlala indima ku-biogenesis ye-mitochondrial, i-homeostasis ye-metabolic, kanye nokuphila isikhathi eside. Ngenxa yalokho, izandulela ze-NAD+ ziyaphenywa ukuze kutholakale amandla azo okunciphisa ukwehla okuhlobene nokuguga, ukusekela ukuguga okunempilo, kanye nokubhekana nokungalingani kwe-metabolic okuhlobene nezimo ezifana nokukhuluphala nesifo sikashukela. Ngaphezu kwalokho, i-NAD+ iyindawo enesithakazelo esikhulayo kwezemidlalo kanye ne-physiology yokuzivocavoca ngenxa yokubandakanyeka kwayo ekusetshenzisweni kwamandla kanye nomsebenzi we-mitochondrial. Izifundo ezihlola ukuguqulwa kwe-NAD+ maqondana nokusebenza kokuzivocavoca, ukululama kwemisipha, kanye namandla okukhuthazela ziyaqhubeka, kanye nemiphumela engaba khona ekusebenzeni kwezemidlalo kanye nokuqina komzimba. Sekukonke, i-NAD+ kanye nezandulela zayo zimelela indawo esebenzayo yophenyo lwesayensi enezinhlelo zokusebenza ezingaba khona ezihlanganisa ukuguga, impilo yamaseli, i-metabolism, kanye ne-physiology yokuzivocavoca, okubonisa indawo ebanzi neguqukayo yocwaningo kanye nokubaluleka okungenzeka kokwelapha.